Core B The functions of the ANIMAL TISSUE CORE FACILITY can be separated into 2 subcores, the ANIMAL SUBCORE and the TISSUE SUBCORE. The animal subcore will be responsible for ordering animals, training and overseeing work with rodents, perform aspects of rodent studies and canine studies along with the project PI and oversee the collection of animal tissues for immunohistochemistry analysis of signal transduction pathways. The rationale for the animal subcore is to standardize where the animals are purchased, how they are handled (including anesthesia), tissue procurement, etc. All aspects the animal subcore will be the responsibility of Dr. Evans. The tissue subcore can be divided into three general tasks: (1) Staining and pathology review of human and animal specimens (2) Analysis of signal transduction pathways and (3) All aspects of investigation of hypoxia based on EF5 and control studies of EF3. Dr. Evans will be responsible for Task 3 and Dr. Lai will be responsible for Tasks 1 and 2. By having all tissue staining and analysis performed by a central pathology service, consistency of reagents, techniques and analysis will be attained. The EF5/EF3 staining techniques and control studies are require special equipment, are complex and comparisons between and within patients are best done by a single Research Specialist. By having the core perform all the EF5 staining studies and the EF3 control studies, this consistency will be guaranteed.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA087971-10
Application #
8555158
Study Section
Special Emphasis Panel (ZCA1-GRB-P (O1))
Project Start
2000-07-01
Project End
2014-01-31
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
10
Fiscal Year
2012
Total Cost
$216,781
Indirect Cost
$78,833
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kim, Michele M; Ghogare, Ashwini A; Greer, Alexander et al. (2017) On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling. Phys Med Biol 62:R1-R48
Friedberg, Joseph S; Simone 2nd, Charles B; Culligan, Melissa J et al. (2017) Extended Pleurectomy-Decortication-Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years. Ann Thorac Surg 103:912-919
Penjweini, Rozhin; Kim, Michele M; Zhu, Timothy C (2017) Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy. Med Phys 44:3767-3775
Ahn, Peter H; Finlay, Jarod C; Gallagher-Colombo, Shannon M et al. (2017) Lesion Oxygenation Associates with Clinical Outcomes in Premalignant and Early Stage Head and Neck Tumors Treated on a Phase 1 Trial of Photodynamic Therapy. Photodiagnosis Photodyn Ther :
Yan, Lesan; Miller, Joann; Yuan, Min et al. (2017) Improved Photodynamic Therapy Efficacy of Protoporphyrin IX-Loaded Polymeric Micelles Using Erlotinib Pretreatment. Biomacromolecules 18:1836-1844
Penjweini, Rozhin; Kim, Michele M; Liu, Baochang et al. (2017) Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling [J. Biophotonics 9, No. 11-12, 1344-1354 (2016)]. J Biophotonics 10:473-474
Kennedy, Gregory Thomas; Newton, Andrew; Predina, Jarrod et al. (2017) Intraoperative near-infrared imaging of mesothelioma. Transl Lung Cancer Res 6:279-284
Zhu, Timothy C; Kim, Michele M; Ong, Yi-Hong et al. (2017) A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT. Proc SPIE Int Soc Opt Eng 10047:
Gemmell, Nathan R; McCarthy, Aongus; Kim, Michele M et al. (2017) A compact fiber-optic probe-based singlet oxygen luminescence detection system. J Biophotonics 10:320-326
Kim, Michele M; Penjweini, Rozhin; Zhu, Timothy C (2017) Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy. J Biomed Opt 22:28002

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