Core D: This Program Project (PPG) comprises a highly integrated effort between a number of programs, departments and schools within the University of Pennsylvania (PENN) and Roswell Park Cancer Institute (RPCI). The complimentary and interwoven nature of the aims for the projects and cores supports and encourages extensive sharing of data, tissues and core services. This synergistic design allows concurrent, bidirectional bedside-bench translation, where causal/mechanistic relationships can be established for new clinical trial observations and novel mechanisms can be evaluated for clinical relevance on an ongoing, rapidly updating basis. The main purpose of the Administrative Core is to provide an organizational framework that facilitates and oversees these collaborations, while avoiding dysfunctional micromanagement to keep the effort as a whole centered on the two major themes for this grant: 1) understanding the mechanisms and clinical contribution of pleural photodynamic therapy (pPDT) in patients undergoing radical pleurectomy (RP) and 2) obtaining improved mechanistic understanding of the impact of surgical resection on pPDT efficacy.
The specific aims for the Administrative Core are as follows:
Aim 1) Coordinate and supervise research efforts;
Aim 2) Enhance communication and collaboration;
Aim 3) Provide administrative and regulatory support.
Core D This Program Project (PPG) comprises a highly integrated effort between a number of programs, departments and schools within the University of Pennsylvania (PENN) and Roswell Park Cancer Institute (RPCI). The complimentary and interwoven nature of the aims for the projects and cores supports and encourages extensive sharing of data, tissues and core services. The Administrative Core D will provide necessary coordination for the success of this program as a whole.
|Kim, Michele M; Darafsheh, Arash; Ahmad, Mahmoud et al. (2016) PDT Dose Dosimeter for Pleural Photodynamic Therapy. Proc SPIE Int Soc Opt Eng 9694:96940Y|
|Sterman, Daniel H; Alley, Evan; Stevenson, James P et al. (2016) Pilot and Feasibility Trial Evaluating Immuno-Gene Therapy of Malignant Mesothelioma Using Intrapleural Delivery of Adenovirus-IFNÎ± Combined with Chemotherapy. Clin Cancer Res 22:3791-800|
|Ong, Yi Hong; Zhu, Timothy C (2016) Analytic function for predicting light fluence rate of circular fields on a semi-infinite turbid medium. Opt Express 24:26261-26281|
|Ghogare, Ashwini A; Miller, Joann M; Mondal, Bikash et al. (2016) Fluorinated Photodynamic Therapy Device Tips and their Resistance to Fouling for In Vivo Sensitizer Release. Photochem Photobiol 92:166-72|
|Grossman, Craig E; Carter, Shirron L; Czupryna, Julie et al. (2016) Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity. Int J Mol Sci 17:|
|Penjweini, Rozhin; Kim, Michele M; Dimofte, Andrea et al. (2016) Deformable medical image registration of pleural cavity for photodynamic therapy by using finite-element based method. Proc SPIE Int Soc Opt Eng 9701:970106|
|Zhu, Timothy C; Lu, Amy; Ong, Yi-Hong (2016) An improved analytic function for predicting light fluence rate in circular fields on a semi-infinite geometry. Proc SPIE Int Soc Opt Eng 9706:97061D|
|Penjweini, Rozhin; Kim, Michele M; Liu, Baochang et al. (2016) Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling. J Biophotonics 9:1344-1354|
|Penjweini, Rozhin; Kim, Michele M; Finlay, Jarod C et al. (2016) Investigating the impact of oxygen concentration and blood flow variation on photodynamic therapy. Proc SPIE Int Soc Opt Eng 9694:|
|Gemmell, Nathan R; McCarthy, Aongus; Kim, Michele M et al. (2016) A compact fiber-optic probe-based singlet oxygen luminescence detection system. J Biophotonics :|
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