Program Integration and Management Abstract: This is the A1 competitive renewal application of a program project that builds on our success in the development of intraoperative photodynamic therapy (PDT) following tumor resection for patients with serosal (peritoneal and pleural) malignancies. We now propose to identify and study PDT-induced local and systemic responses that uniquely interact with the surgical environment to determine local control and long-term outcome. The overall goals of this PPG involve 1) understanding the mechanisms and clinical contribution of pleural photodynamic therapy (pPDT) in patients undergoing radical pleurectomy (RP) and 2) obtaining improved mechanistic understanding of the impact of surgical resection on pPDT efficacy. The integrated PPG structure is absolutely ideal for this type of multidisciplinary team project; thus, the overall goals for the coordination and integration of projects and cores are as follows:
Aim 1 is to provide organizational framework that promotes project integration through the complimentary and interwoven nature of the aims for the projects and cores that supports and encourages extensive sharing of data, tissues and core services.
Aim 2 is to provide organizational framework that minimizes avoidable heterogeneity through the use of complimentary analyses of common clinical samples, integrated studies of standardized animal models, standardized approaches and procedures and quality assurance and training programs.
Aim 3 is to manage projects and resources to maximize the potential impact of the PPG studies through extensive infrastructure and administrative support to coordinate and supervise research efforts and enhance collaboration and communication. This synergistic design allows concurrent, bidirectional bedside-bench translation, where causal/mechanistic relationships can be established for new clinical trial observations and novel mechanisms can be evaluated for clinical relevance on an ongoing, rapidly updating basis.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA087971-11A1
Application #
8741246
Study Section
Special Emphasis Panel (ZCA1-RPRB-B (M1))
Project Start
2000-07-01
Project End
2015-06-30
Budget Start
2014-09-10
Budget End
2015-06-30
Support Year
11
Fiscal Year
2014
Total Cost
$2
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Simone 2nd, Charles B; Cengel, Keith A (2014) Photodynamic therapy for lung cancer and malignant pleural mesothelioma. Semin Oncol 41:820-30
Han, Sung Wan; Mesquita, Rickson C; Busch, Theresa M et al. (2014) A Method for Choosing the Smoothing Parameter in a Semi-parametric Model for Detecting Change-points in Blood Flow. J Appl Stat 41:26-45
Liang, Xing; Wang, Ken Kang-Hsin; Zhu, Timothy C (2013) Feasibility of interstitial diffuse optical tomography using cylindrical diffusing fibers for prostate PDT. Phys Med Biol 58:3461-80
Maas, Amanda L; Carter, Shirron L; Wileyto, E Paul et al. (2012) Tumor vascular microenvironment determines responsiveness to photodynamic therapy. Cancer Res 72:2079-88
Friedberg, Joseph S; Culligan, Melissa J; Mick, Rosemarie et al. (2012) Radical pleurectomy and intraoperative photodynamic therapy for malignant pleural mesothelioma. Ann Thorac Surg 93:1658-65; discussion 1665-7
Grossman, Craig E; Pickup, Stephen; Durham, Amy et al. (2011) Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model. Lasers Surg Med 43:663-75
Sandell, Julia L; Zhu, Timothy C (2011) A review of in-vivo optical properties of human tissues and its impact on PDT. J Biophotonics 4:773-87
Busch, Theresa M; Wang, Hsing-Wen; Wileyto, E Paul et al. (2010) Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate. Radiat Res 174:331-40
Wang, Ken Kang-Hsin; Finlay, Jarod C; Busch, Theresa M et al. (2010) Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling. J Biophotonics 3:304-18
Busch, Theresa M (2010) Hypoxia and perfusion labeling during photodynamic therapy. Methods Mol Biol 635:107-20

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