This Program Project will be formally aligned under the Linus Pauling Institute (LPI) at Oregon State University (OSU), Housing of the Program Project under LPI provides a pre-existing organizational structure for administration of the grant, and for promoting scientific interaction with other research centers on campus with allied research interests. The latter include the NIEHS-funded Environmental Health Sciences Center (EHSC) and the Center for Genome Research and Biocomputing (CGRB). This alignment also provides direct access to the highest levels of university administration. Roderick Dashwood, the Principal Investigator of the Program Project, currently serves as Chief of the Cancer Chemoprotection Program in LPI, Leader of the EHSC Environmental Mutagenesis &Carcinogenesis research core, and Professor of Environmental &Molecular Toxicology. Dr. Dashwood's oversight of Core B will be carried out with assistance from Barbara McVicar, senior office specialist and Assistant to the Director and Cathy Abney, accounts manager. Core B will provide liaison with NIH in all application and reporting responsibilities, including compiling and submission of all reports and non-competing renewals required by NIH, and obtaining approvals of human subjects and vertebrate animals. This core will directly administer the budgets for all three Projects, and for the Epigenetic/Translational Biomarkers (ETB) Core, coordinate regularly scheduled Project meetings, and organize all activities associated with the annual External Advisory Committee (EAC) meetings. The EAC consists of Dr. Johanna W. Lampe, Fred Hutchinson Cancer Research Center, Dr. William Helferich, University of Illinois, and Dr. Paul Limburg, Mayo Clinic. This committee of distinguished scientists has already functioned to guide the investigators in the preparation of this competing continuation, with reviews and helpful suggestions pertaining to specific Project elements, according to their areas of expertise. In the future, EAC members will assess research progress, advise the PI and Project Leaders on how the Program Project may best respond to advances in the field of cancer chemoprevention, and discuss with OSU research administration the university commitments that may be necessary to facilitate such responses.
In addition to genetic changes affecting DNA sequence information, we now realize that cancer development involves so-called epigenetic events, which represent a major new research priority area at NIH. One aspect of intense current interest concerns the histone (protein) modifications that silence genes in cancer and development. We find that dietary agents can reverse such modifications, thereby re-expressing tumor suppressor genes and triggering cancer cells to arrest their growth and/or commit suicide via apoptosis.
|Johnson, Gavin S; Li, Jia; Beaver, Laura M et al. (2016) A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a co-activator of NQO1 in sulforaphane-treated colon cancer cells. Mol Nutr Food Res :|
|Wang, Rong; Kang, Yuki; LÃ¶hr, Christiane V et al. (2016) Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer. Cancer Lett 381:341-8|
|Watson, Gregory W; Wickramasekara, Samanthi; Fang, Yufeng et al. (2016) HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells. Exp Biol Med (Maywood) 241:1177-85|
|Abbas, Ata; Hall, J Adam; Patterson 3rd, William L et al. (2016) Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines. Biochem Cell Biol 94:71-81|
|Ertem, Furkan; Dashwood, Wan-Mohaiza; Rajendran, Praveen et al. (2016) Development of a murine colonoscopic polypectomy modelÂ (withÂ videos). Gastrointest Endosc 83:1272-6|
|Zhang, Zhenzhen; Atwell, Lauren L; Farris, Paige E et al. (2016) Associations between cruciferous vegetable intake and selected biomarkers among women scheduled for breast biopsies. Public Health Nutr 19:1288-95|
|Kim, Hyemee; Banerjee, Nivedita; Ivanov, Ivan et al. (2016) Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Mol Nutr Food Res 60:1912-23|
|Kim, Eunah; Bisson, William H; LÃ¶hr, Christiane V et al. (2016) Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors. Curr Top Med Chem 16:714-31|
|Harper Jr, Tod A; MorrÃ©, Jeff; Lauer, Fredine T et al. (2015) Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS. Mutat Res Genet Toxicol Environ Mutagen 782:51-6|
|Watson, Gregory W; Wickramasekara, Samanthi; Fang, Yufeng et al. (2015) Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells. Mol Nutr Food Res 59:1954-61|
Showing the most recent 10 out of 111 publications