The Administrative Core (ADM) of the Program Project in Structural Cell Biology of DNA Repair Machines (SBDR) will coordinate all administrative aspects of the Program and facilitate interaction among the Investigators. Our goal is to maintain the SBDR program coherence, focus, and progress to ensure the successful conduct of the proposed research. Specifically, the ADM Core will provide administrative infrastructure, ensure milestones are met, and promote interaction and efficient communication among SBDR Projects and Cores and with the wider DNA repair and cancer research communities. The infrastructure for the Administrative Core is already in place and operating efficiently, having been established during the nine-year history of SBDR. ADM Core goals will be accomplished through three specific aims:
Aim 1. Provide management support to the SBDR Program.
Aim 2. Facilitate and monitor SBDR progress and effective allocation of shared research Core efforts.
Aim 3. Ensure effective communication between the NCI, investigators, and postdoctoral fellows. Management of the SBDR Program will be provided by an administrative structure that formally consists of Drs. Priscilla Cooper and John Tainer as Core Director and Deputy Director, respectively, together with the Program Communications Coordinator and an Executive Committee comprised of the Project Leaders, selected additional Sr. Investigators, and the EMB and SCB Core Directors. An External Advisory Board comprised of leading investigators in DNA repair, structural biology, and cancer biology will annually review the progress of the Program and make recommendations to the ADM Core Director and Deputy Director. The successful operation of the SBDR Program for 21 investigators at 15 institutions depends heavily on excellent communications and program management capabilities. The Administrative Core serves to provide a central point of contact for all operational matters with in SBDR. This includes providing budget management support, coordinating preparation of annual progress reports, monitoring progress toward overall SBDR goals, maintaining effective and equitable access to the shared resource Cores, and organizing regular teleconferences and web-based conferencing, postdoc webinars, and annual workshops for all investigators and SBDR fellows.
The overall goal of the SBDR Program is to develop detailed structural and mechanistic understanding of DNA Repair machines to enable identification of specific ways to control biological outcomes of cellular responses to DNA damage for cancer interventions. This effort involves experimental cycles between structural and functional studies in six Projects with 21 investigators. The ADM Core enables this multi-institutional effort by providing overall management of SBDR, facilitating communications, and fostering Program integration.
|Feldkamp, Michael D; Mason, Aaron C; Eichman, Brandt F et al. (2014) Structural analysis of replication protein A recruitment of the DNA damage response protein SMARCAL1. Biochemistry 53:3052-61|
|Groocock, Lynda M; Nie, Minghua; Prudden, John et al. (2014) RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. EMBO Rep 15:601-8|
|Paull, Tanya T; Deshpande, Rajashree A (2014) The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes. Exp Cell Res 329:139-47|
|Shibata, Atsushi; Moiani, Davide; Arvai, Andrew S et al. (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell 53:7-18|
|Mahaney, Brandi L; Lees-Miller, Susan P; Cobb, Jennifer A (2014) The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining. DNA Repair (Amst) 14:9-16|
|Frank, Andreas O; Vangamudi, Bhavatarini; Feldkamp, Michael D et al. (2014) Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem 57:2455-61|
|Wu, Ching-Shyi; Ouyang, Jian; Mori, Eiichiro et al. (2014) SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes Dev 28:1472-84|
|Davis, Anthony J; Chen, Benjamin P C; Chen, David J (2014) DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) 17:21-9|
|Zhao, Weixing; Saro, Dorina; Hammel, Michal et al. (2014) Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res 42:906-17|
|Longerich, Simonne; Kwon, Youngho; Tsai, Miaw-Sheue et al. (2014) Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA. Nucleic Acids Res 42:5657-70|
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