Abstract

The Morphology Core (Core B) has the following responsibilities: 1. Provide the Pis and other investigators of the four projects with expert advice in the selection and application of optimal morphological techniques to address specific questions and problems in their research. 2. Perform advanced morphological applications that will include in situ hybridization, confocal laser scanning microscopy, plastic one micron section light microscopy, transmission electron microscopy, electron microscopic immuno(gold)cytochemistry, and laser capture microdissection. 3. Provide expertise in interpreting results obtained with the various morphological techniques. 4. Allocate the equipment, personnel and other resources fairly and to the optimal performance of the program project'

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA092644-10
Application #
8459038
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
10
Fiscal Year
2013
Total Cost
$134,970
Indirect Cost
$43,073

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Sitohy, Basel; Chang, Sunghee; Sciuto, Tracey E et al. (2017) Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels. Am J Pathol 187:2337-2347
Gross, Kayla; Wronski, Ania; Skibinski, Adam et al. (2016) Cell Fate Decisions During Breast Cancer Development. J Dev Biol 4:4
Sedic, Maja; Kuperwasser, Charlotte (2016) BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer. Cell Cycle 15:621-7
Sedic, Maja; Skibinski, Adam; Brown, Nelson et al. (2015) Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun 6:7505
Mazumdar, Sohini; Arendt, Lisa M; Phillips, Sarah et al. (2015) CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS One 10:e0121281
Dvorak, Harold F (2015) Tumor Stroma, Tumor Blood Vessels, and Antiangiogenesis Therapy. Cancer J 21:237-43
Sciuto, Tracey E; Merley, Anne; Lin, Chi-Iou et al. (2015) Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells. Biochem Biophys Res Commun 465:338-43
Kaunisto, Aura; Henry, Whitney S; Montaser-Kouhsari, Laleh et al. (2015) NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer. Mol Oncol 9:1140-54
Dvorak, Harold F (2015) Tumors: wounds that do not heal-redux. Cancer Immunol Res 3:1-11
Lin, Chi-Iou; Merley, Anne; Sciuto, Tracey E et al. (2014) TM4SF1: a new vascular therapeutic target in cancer. Angiogenesis 17:897-907

Showing the most recent 10 out of 117 publications