The Administrative Core will have eight central goals: (a) facilitating interaction and communication along the participating research groups; (b) forming a repository of information for research resources generated by program investigators available to other project investigators; (c) obtaining constructive criticism from extramural and intramural scientists that will help investigators to obtain their research goals; (d) coordinating Resource availability to the broad scientific community (i.e. Resource Sharing); (e) providing biostatistical support to all of the projects; (f) performing the reporting tasks required by the NIH; (g) ensuring appropriate approvals (i.e. radiation, human subjects, animal welfare, DNA) are obtained and adhered to; and (h) providing administrative services to the project as a whole. The Core will be directed by Dr. Evan Keller, fiscal administration and general program activities will be performed by Ms. Roberta Feltner. Dr. Jeremy Taylor and Ms. Stephanie Daignault will provide biostatistical support. These goals will be accomplished by a variety of activities including: - Weekly Project and Core Leader meetings - Monthly Project Team meetings attended by all lab members of all Projects. - Annual one-day visits by our External Advisory Board - Annual one-day visits with our Internal Advisory Board - Biostatistical review of all animal projects prior to initiation of the project to ensure appropriate Power.

Public Health Relevance

Core A: Administrative Core Project Narrative Bone metastasis is a common problem of prostate cancer that affects many men. This core will oversee the operations of the entire Program to ensure that it moves forward in a direction that addresses this important clinical problem.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA093900-12
Application #
9163104
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
12
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Axelrod, Haley D; Valkenburg, Kenneth C; Amend, Sarah R et al. (2018) AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer. Mol Cancer Res :
de Groot, Amber E; Pienta, Kenneth J (2018) Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages. Oncotarget 9:20908-20927
Roca, Hernan; Jones, Jacqueline D; Purica, Marta C et al. (2018) Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone. J Clin Invest 128:248-266

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