The Biostatistics Core under the Directorship of Dr. Phyllis Gimotty has vast biostatistical experience, especially in cancer biology and therapy. The goals of the Biostatistics Core are to provide biostatistical expertise to Program Project investigators and their personnel, and in collaboration with these investigators to use statistical models and other statistical techniques to better understand the etiology and progression of esophageal cancer. The Biostatistics Core faculty and staff have vast experience in cancer research and extensive experience with the proposed statistical methodologies and their application to the research studies proposed in this Program Project. They will provide expertise in the following areas to support its research objectives: (1) statistical methods to study associations among gene-related factors and/or among associated protein-related factors, as well as factors that influence tumor growth in different biological models;(2) statistical design and evaluation strategies to assess the impact of experimental interventions in genes on relevant biological outcomes (cell proliferation and apoptosis, tumor growth and development, therapeutic response);and (3) statistical decision making tools to make scientifically valid statements related to key scientific hypotheses. The Biostatistics Core members will collaborate with project investigators to interpret and synthesize study findings, collaborate on the preparation of manuscripts and maintain a database library linking all of the analytic databases. These collaborations will ensure that the projects continue to have high quality study designs and statistical analysis plans, which will provide an outstanding foundation for statistical models and inferences made from the experimental data. This Core is dynamic in responding to evolving P01 needs, anticipating future P01 directions, and integrating new statistical methodologies and models,

Public Health Relevance

(Seeinstructions): This Core is of vital importance to ensure that the experimental design and data analyses within the Projects are done in a rigorous, integrated fashion, and to forge new directions in the translational components of the Program Project. This Core has a wealth of experience in cancer research that is used by the Program Project.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098101-09
Application #
8380744
Study Section
Special Emphasis Panel (ZCA1-RPRB-O)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$94,472
Indirect Cost
$28,068
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Zhou, Jin; Wu, Zhong; Wong, Gabrielle et al. (2017) CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma. Nat Commun 8:13897
Whelan, K A; Chandramouleeswaran, P M; Tanaka, K et al. (2017) Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance. Oncogene 36:4843-4858
Whelan, Kelly A; Merves, Jamie F; Giroux, Veronique et al. (2017) Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis. Gut 66:1197-1207
Harmeyer, Kayla M; Facompre, Nicole D; Herlyn, Meenhard et al. (2017) JARID1 Histone Demethylases: Emerging Targets in Cancer. Trends Cancer 3:713-725
Facompre, Nicole D; Sahu, Varun; Montone, Kathleen T et al. (2017) Barriers to generating PDX models of HPV-related head and neck cancer. Laryngoscope 127:2777-2783
Yoshioka, Masahiro; Ohashi, Shinya; Ida, Tomomi et al. (2017) Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells. J Exp Clin Cancer Res 36:101
Natsuizaka, Mitsuteru; Whelan, Kelly A; Kagawa, Shingo et al. (2017) Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma. Nat Commun 8:1758
Giroux, VĂ©ronique; Lento, Ashley A; Islam, Mirazul et al. (2017) Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration. J Clin Invest 127:2378-2391
Fichter, Christiane Daniela; Przypadlo, Camilla Maria; Buck, Achim et al. (2017) A new model system identifies epidermal growth factor receptor-human epidermal growth factor receptor 2 (HER2) and HER2-human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion. J Pathol 243:481-495
Facompre, Nicole D; Harmeyer, Kayla M; Sole, Xavier et al. (2016) JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers. Cancer Res 76:5538-49

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