The Administrative Core will provide comprehensive and cohesive support in administrative, fiscal and programmatic aspects of the Program Project. It will also interface with the University of Pennsylvania, the Wistar Institute, Fox Chase Cancer Center and the National Cancer Institute (NCI). The Administrative Core, in geographical proximity to the scientific core facilities and the laboratories of the project leaders, will serve many organizational and fiscal functions. These include generation and analysis of monthly budget reports, interfacing with the medical school's research services, coordinating clinical/translational programs, and completing NCI requirements. In addition, the administrative core will continue to coordinate monthly meetings with the project and core facilities leaders;weekly core facilities'meetings;regular research seminars/journal clubs/laboratory meetings;maintain a library, newsletter and website;and promote the program project within the university and medical school (especially as it relates to the internal advisory board-lAB), as well as regionally and nationally. Importantly, the Core will organize the annual conference/retreat in conjunction with the review by the external advisory board (EAB). All IAB and EAB reports will be organized by the Core that will be shared with the Dean, Cancer Center Director, Wistar Institute Director and the NCI. As additional measures, the Core will organize workshops in grant writing, manuscript writing, and career development for students, postdoctoral fellows and junior faculty in the Program Project. It will expand the human tissue banking efforts of the Morphology and Molecular Biology Cores, promote the relational databases of the Molecular Biology Core, ensure appropriate bioinformatics support through the Molecular Biology Core and integrate the new Biostatistics Core. The Administrative Core will advance the innovative and far-reaching goals articulated and envisioned by the Program Project. In aggregate, the administrative core, already in existence, will enhance the intellectual, scientific, structural and fiscal components of the Program Project. Individually and together, Drs. Rustgi and Herlyn and Ms. Hay have vast experience in administration and ensuring thematic integration between the Projects and Cores.

Public Health Relevance

This Core is critical to the growth and expansion of the Program Project at Penn, regionally, nationally, and internationally. It achieves prominence of the Program Project by integrating the Projects, providing support for the other cores, nurturing new investigators-into the field, expanding the repetoire of the databases/reagents of the Program Project, and working closely with institutional leadership and the NCI.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098101-10
Application #
8527494
Study Section
Special Emphasis Panel (ZCA1-RPRB-O)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$94,206
Indirect Cost
$28,059
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kagawa, S; Natsuizaka, M; Whelan, K A et al. (2015) Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene 34:2347-59
Natsuizaka, Mitsuteru; Kinugasa, Hideaki; Kagawa, Shingo et al. (2014) IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment. Am J Cancer Res 4:29-41
Hong, Yong Sang; Kim, Jihun; Pectasides, Eirini et al. (2014) Src mutation induces acquired lapatinib resistance in ERBB2-amplified human gastroesophageal adenocarcinoma models. PLoS One 9:e109440
Habibollahi, Peiman; Waldron, Todd; Heidari, Pedram et al. (2014) Fluorescent nanoparticle imaging allows noninvasive evaluation of immune cell modulation in esophageal dysplasia. Mol Imaging 13:1-11
Hartman, Kira G; Bortner Jr, James D; Falk, Gary W et al. (2014) Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems. Exp Biol Med (Maywood) 239:1108-23
Xu, Chunxiao; Fillmore, Christine M; Koyama, Shohei et al. (2014) Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell 25:590-604
Watanabe, Hideo; Ma, Qiuping; Peng, Shouyong et al. (2014) SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas. J Clin Invest 124:1636-45
Wong, Gabrielle S; Habibollahi, Peiman; Heidari, Pedram et al. (2013) Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice. Gastroenterology 144:294-7
Desai, Brijal M; Villanueva, Jessie; Nguyen, Thierry-Thien K et al. (2013) The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling. PLoS One 8:e59588
Kadaba, Raghu; Birke, Hanna; Wang, Jun et al. (2013) Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes. J Pathol 230:107-17

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