Cigarette smoking among adolescents and young adults remains one of the most important public health challenges. Almost all smokers begin smoking while in their adolescent years, but smoking becomes entrenched during the young adult years. Understanding more about the factors that promote or protect against smoking progression and nicotine dependence may help us to develop more effective interventions. Also important is understanding how the transition from adolescence to young adulthood, a transition that brings multiple life changes and heightened risk for behavioral problems, influences smoking patterns that have been set in motion during adolescence. This program project will provide an in-depth, multi-method study of the patterns and predictors of smoking patterns from experimentation onward, from adolescence through young adulthood. This continuation builds on and extends our current work by proposing to continue to follow a high risk cohort of individuals, first identified and characterized during mid-adolescence, and who are now in young adulthood. We propose to follow these individuals through their early twenties, the period of highest risk for establishment of smoking and dependence. We will maintain our focus on the social emotional contexts that may influence smoking, and extend this to explore promising genetic markers for the development of dependence. Across projects, we will also characterize, through multiple methods, the development of dependence from the early stages of smoking onward. The projects are linked conceptually through their common consideration of factors that influence the patterns of smoking from adolescence through young adulthood, and methodologically, through their use of a common cohort of participants. Our overriding interest is in identifying, describing, and predicting patterns of progression of smoking and nicotine dependence, considering the dynamic interplay of genetic, social, and emotional contexts. Our proposed program project comprises four research projects and three cores. The four research projects are: 1) Patterns and Predictors of Smoking from Adolescence to Young Adulthood; 2) Proximal Contexts of Young Adult Smoking Patterns; 3) Emotional Indices of Withdrawal in Young Adult Smokers;and 4) Genetic Risk Markers for Smoking Progression. Our three Cores are: 1) Scientific/Administrative Core; 2) Participant Interaction Core;and 3) Data Management, Measurement, and Statistics Core.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098262-08
Application #
8300184
Study Section
Special Emphasis Panel (ZCA1-RPRB-7 (M1))
Program Officer
Morgan, Glen D
Project Start
2002-12-01
Project End
2015-07-31
Budget Start
2012-09-18
Budget End
2013-07-31
Support Year
8
Fiscal Year
2012
Total Cost
$2,366,896
Indirect Cost
$713,062
Name
University of Illinois at Chicago
Department
Administration
Type
Schools of Public Health
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Cannon, Dale S; Mermelstein, Robin J; Medina, Tait R et al. (2016) CYP2A6 Effects on Subjective Reactions to Initial Smoking Attempt. Nicotine Tob Res 18:637-41
Dierker, Lisa; Selya, Arielle; Rose, Jennifer et al. (2016) Nicotine Dependence and Alcohol Problems from Adolescence to Young Adulthood. Dual Diagn (Foster City) 1:
Crane, Natania A; Gorka, Stephanie M; Giedgowd, Grace E et al. (2016) Adolescent's respiratory sinus arrhythmia is associated with smoking rate five years later. Biol Psychol 118:107-13
Pugach, Oksana; Cannon, Dale S; Weiss, Robert B et al. (2016) Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers. Nicotine Tob Res :
Hertel, Andrew W; Mermelstein, Robin J (2016) Smoker identity development among adolescents who smoke. Psychol Addict Behav 30:475-83
Piasecki, Thomas M; Hedeker, Donald; Dierker, Lisa C et al. (2016) Progression of nicotine dependence, mood level, and mood variability in adolescent smokers. Psychol Addict Behav 30:484-93
Cannon, Dale S; Medina, Tait R; Mermelstein, Robin J et al. (2016) CYP2A6 Longitudinal Effects in Young Smokers. Nicotine Tob Res 18:196-203
Hedeker, Donald; Mermelstein, Robin J; Demirtas, Hakan et al. (2016) A Mixed-effects Location-Scale Model for Ordinal Questionnaire Data. Health Serv Outcomes Res Methodol 16:117-131
Gao, Weihua; Hedeker, Donald; Mermelstein, Robin et al. (2016) A scalable approach to measuring the impact of nonignorable nonresponse with an EMA application. Stat Med 35:5579-5602
Schuster, Randi Melissa; Mermelstein, Robin J; Hedeker, Donald (2016) Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use. Addiction 111:1466-76

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