It has become increasingly clear that young adulthood represents a time of heightened vulnerability to smoking progression and development of nicotine dependence. Nonetheless, the mechanisms underlying smoking behavior in this age group are still not well understood. Given that the majority of adult smokers smoke as a means of regulating affect, including negative affect attributable to withdrawal, the present study proposes to assess, under controlled laboratory conditions, the effect of smoking and nicotine on affective response in young adult smokers. Similar experimental approaches have been used to great effect with other drugs of abuse, yet surprisingly, other than our own previous work in this area, few empirical investigations have assessed both nicotine administration and deprivation effects on emotional response in young adults. Knowledge of such effects is crucial to furthering our understanding of the processes governing development of nicotine dependence, as well as to assess individual differences in the manifestation of withdrawal and smoking effects on emotional response. Toward these ends, the proposed laboratory study will examine the acute effects of cigarette smoking and nicotine on emotional response and working memory capacity in 147 young adult smokers. Participants will attend three randomized laboratory sessions during which they will: smoke a nicotine cigarette, smoke a denicotinized cigarette, and not smoke (deprivation condition). Hence, this study design will allow for fine-grained assessment of acute smoking, nicotine, and deprivation effects. A multidimensional approach to the measurement of emotion will be used, drawing upon self-report measures of positive and negative affect, heart rate, skin conductance, fear potentiated startle eye blink response, and facial electromyography (zygomatic and corrugator muscle groups). Standardized measures of craving will also be employed both within and across the three sessions. Finally, because nicotine administration is thought to increase working memory in adult smokers, and deprivation, reduce it, a well-validated task measuring working memory capacity will also be employed. Assessment of individual differences in these respective variables will also allow for assessment of whether such differences are predictive of future smoking behavior.

Public Health Relevance

Cigarette smoking among adolescents and young adults remains a growing public health concern. The proposed study will build upon our previous work

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098262-09
Application #
8546693
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
9
Fiscal Year
2013
Total Cost
$135,924
Indirect Cost
Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Cannon, Dale S; Mermelstein, Robin J; Medina, Tait R et al. (2016) CYP2A6 Effects on Subjective Reactions to Initial Smoking Attempt. Nicotine Tob Res 18:637-41
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Crane, Natania A; Gorka, Stephanie M; Giedgowd, Grace E et al. (2016) Adolescent's respiratory sinus arrhythmia is associated with smoking rate five years later. Biol Psychol 118:107-13
Pugach, Oksana; Cannon, Dale S; Weiss, Robert B et al. (2016) Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers. Nicotine Tob Res :
Hertel, Andrew W; Mermelstein, Robin J (2016) Smoker identity development among adolescents who smoke. Psychol Addict Behav 30:475-83
Piasecki, Thomas M; Hedeker, Donald; Dierker, Lisa C et al. (2016) Progression of nicotine dependence, mood level, and mood variability in adolescent smokers. Psychol Addict Behav 30:484-93
Cannon, Dale S; Medina, Tait R; Mermelstein, Robin J et al. (2016) CYP2A6 Longitudinal Effects in Young Smokers. Nicotine Tob Res 18:196-203
Hedeker, Donald; Mermelstein, Robin J; Demirtas, Hakan et al. (2016) A Mixed-effects Location-Scale Model for Ordinal Questionnaire Data. Health Serv Outcomes Res Methodol 16:117-131
Gao, Weihua; Hedeker, Donald; Mermelstein, Robin et al. (2016) A scalable approach to measuring the impact of nonignorable nonresponse with an EMA application. Stat Med 35:5579-5602
Schuster, Randi Melissa; Mermelstein, Robin J; Hedeker, Donald (2016) Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use. Addiction 111:1466-76

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