Young adulthood is an important period in the development of regular cigarette smoking and nicotine dependence. Dramatic increases in both the prevalence and intensity of smoking occur after age 18. National data show that the prevalence of cigarette smoking is higher among young adults (aged 18-24) than among any other age group, and there is little evidence of a decline in these rates over the past several years. The primary goal of this proposed project is to continue to follow our established cohort of high risk adolescents through the period of young adulthood (approximately ages 19-25 for our cohort), with four annual assessments, and to examine the contributions of social and emotional contextual factors to the development of smoking patterns as they emerge from adolescence through young adulthood. We will examine how changes in social contexts (friendship networks, life transitions) may serve as markers for smoking change, and how specific behavioral risk factors (e.g., alcohol and substance use, depression, ADHD symptoms) may confer additional risk in developing nicotine dependence. In addition, we propose to examine, more in-depth, the phenomenon of nicotine dependence across the range of smoking levels, from light and infrequent smokers to more regular and "heavier" smokers, and how nicotine dependence is best assessed and conceptualized at different levels of smoking. This project will take advantage ofthe wealth of rich, longitudinal data already collected on this sample, with a unique opportunity to look specifically at mechanisms that might explain vulnerability to smoking progression and the development of dependence. We will be able to track changes in key variables and smoking from adolescence through young adulthood, and examine how both protective and risk vulnerabilities present during adolescence and emerging adulthood may play a role in predicting changes in smoking behavior. Understanding factors that influence the development of smoking patterns (both escalation and cessation) during the vulnerable period of adolescence to young adulthood is of critical importance for developing future interventions.

Public Health Relevance

Although cigarette smoking typically starts in adolescence, the transition to young adulthood (ages 18-24) brings with it more entrenched patterns of smoking and nicotine dependence. The primary goal of this project is to continue to follow an established cohort of high risk adolescents through the period of young adulthood and to examine the contributions of social and emotional contextual factors to the development of smoking patterns as they emerge from adolescence through young adulthood. Understanding factors that influence the development of smoking patterns (both escalation and cessation) during the vulnerable period of adolescence to young adulthood is of critical importance for developing future interventions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098262-10
Application #
8734234
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
10
Fiscal Year
2014
Total Cost
$246,829
Indirect Cost
$73,275
Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Cannon, Dale S; Mermelstein, Robin J; Medina, Tait R et al. (2016) CYP2A6 Effects on Subjective Reactions to Initial Smoking Attempt. Nicotine Tob Res 18:637-41
Dierker, Lisa; Selya, Arielle; Rose, Jennifer et al. (2016) Nicotine Dependence and Alcohol Problems from Adolescence to Young Adulthood. Dual Diagn (Foster City) 1:
Crane, Natania A; Gorka, Stephanie M; Giedgowd, Grace E et al. (2016) Adolescent's respiratory sinus arrhythmia is associated with smoking rate five years later. Biol Psychol 118:107-13
Pugach, Oksana; Cannon, Dale S; Weiss, Robert B et al. (2016) Classification Tree Analysis as a Method for Uncovering Relations Between CHRNA5A3B4 and CHRNB3A6 in Predicting Smoking Progression in Adolescent Smokers. Nicotine Tob Res :
Hertel, Andrew W; Mermelstein, Robin J (2016) Smoker identity development among adolescents who smoke. Psychol Addict Behav 30:475-83
Piasecki, Thomas M; Hedeker, Donald; Dierker, Lisa C et al. (2016) Progression of nicotine dependence, mood level, and mood variability in adolescent smokers. Psychol Addict Behav 30:484-93
Cannon, Dale S; Medina, Tait R; Mermelstein, Robin J et al. (2016) CYP2A6 Longitudinal Effects in Young Smokers. Nicotine Tob Res 18:196-203
Hedeker, Donald; Mermelstein, Robin J; Demirtas, Hakan et al. (2016) A Mixed-effects Location-Scale Model for Ordinal Questionnaire Data. Health Serv Outcomes Res Methodol 16:117-131
Gao, Weihua; Hedeker, Donald; Mermelstein, Robin et al. (2016) A scalable approach to measuring the impact of nonignorable nonresponse with an EMA application. Stat Med 35:5579-5602
Schuster, Randi Melissa; Mermelstein, Robin J; Hedeker, Donald (2016) Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use. Addiction 111:1466-76

Showing the most recent 10 out of 77 publications