It has become increasingly clear that young adulthood represents a time of heightened vulnerability to smoking progression and development of nicotine dependence. Nonetheless, the mechanisms underlying smoking behavior in this age group are still not well understood. Given that the majority of adult smokers smoke as a means of regulating affect, including negative affect attributable to withdrawal, the present study proposes to assess, under controlled laboratory conditions, the effect of smoking and nicotine on affective response in young adult smokers. Similar experimental approaches have been used to great effect with other drugs of abuse, yet surprisingly, other than our own previous work in this area, few empirical investigations have assessed both nicotine administration and deprivation effects on emotional response in young adults. Knowledge of such effects is crucial to furthering our understanding of the processes governing development of nicotine dependence, as well as to assess individual differences in the manifestation of withdrawal and smoking effects on emotional response. Toward these ends, the proposed laboratory study will examine the acute effects of cigarette smoking and nicotine on emotional response and working memory capacity in 147 young adult smokers. Participants will attend three randomized laboratory sessions during which they will: smoke a nicotine cigarette, smoke a denicotinized cigarette, and not smoke (deprivation condition). Hence, this study design will allow for fine-grained assessment of acute smoking, nicotine, and deprivation effects. A multidimensional approach to the measurement of emotion will be used, drawing upon self-report measures of positive and negative affect, heart rate, skin conductance, fear potentiated startle eye blink response, and facial electromyography (zygomatic and corrugator muscle groups). Standardized measures of craving will also be employed both within and across the three sessions. Finally, because nicotine administration is thought to increase working memory in adult smokers, and deprivation, reduce it, a well-validated task measuring working memory capacity will also be employed. Assessment of individual differences in these respective variables will also allow for assessment of whether such differences are predictive of future smoking behavior.

Public Health Relevance

Cigarette smoking among adolescents and young adults remains a growing public health concern. The proposed study will build upon our previous work

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA098262-10
Application #
8734236
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
10
Fiscal Year
2014
Total Cost
$209,348
Indirect Cost
$73,275
Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Dierker, Lisa; Rose, Jennifer; Selya, Arielle et al. (2015) Depression and nicotine dependence from adolescence to young adulthood. Addict Behav 41:124-8
Nadell, Melanie J; Mermelstein, Robin J; Hedeker, Donald et al. (2015) Work and Non-Work Physical Activity Predict Real-Time Smoking Level and Urges in Young Adults. Nicotine Tob Res 17:803-9
Hedeker, Donald (2015) Methods for Multilevel Ordinal Data in Prevention Research. Prev Sci 16:997-1006
Coon, Hilary; Piasecki, Thomas M; Cook, Edwin H et al. (2014) Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults. Alcohol Clin Exp Res 38:930-7
Pugach, Oksana; Hedeker, Donald; Mermelstein, Robin (2014) A Bivariate Mixed-Effects Location-Scale Model with application to Ecological Momentary Assessment (EMA) data. Health Serv Outcomes Res Methodol 14:194-212
Pugach, Oksana; Hedeker, Donald; Richmond, Melanie J et al. (2014) Modeling mood variation and covariation among adolescent smokers: application of a bivariate location-scale mixed-effects model. Nicotine Tob Res 16 Suppl 2:S151-8
Cannon, Dale S; Mermelstein, Robin J; Hedeker, Donald et al. (2014) Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults. Nicotine Tob Res 16:137-44
Mermelstein, Robin J (2014) Adapting to a changing tobacco landscape: research implications for understanding and reducing youth tobacco use. Am J Prev Med 47:S87-9
Piasecki, Thomas M; Trela, Constantine J; Hedeker, Donald et al. (2014) Smoking antecedents: separating between- and within-person effects of tobacco dependence in a multiwave ecological momentary assessment investigation of adolescent smoking. Nicotine Tob Res 16 Suppl 2:S119-26
Sokolovsky, Alexander W; Mermelstein, Robin J; Hedeker, Donald (2014) Factors predicting compliance to ecological momentary assessment among adolescent smokers. Nicotine Tob Res 16:351-8

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