Abstract

The Administrative core will provide support for each of the projects in this P01 as well as the scientific core.
The aims of the Administrative Core are to ensure that the resources within the P01 are distributed equitably to the investigators and that all rules and regulations of the National Cancer Institute and the National Institutes of Health are followed. The Administration Core will coordinate monthly meetings of the investigators and their laboratories and vacilitate communication between our investigators with the External Advisory Boards. The finances of the P01 will be organized by Mr. James Riley, Business Administrator of the Abramson Family Cancer Research Institute who will meet monthly with the P01 PI and quarterly with each project and core leader. Ms. Erin Podewils will coordinate travel arrangements for the members of the P01 as well as the advisors who will visit Penn. She will also provide administrative suppport for each of the P01 investigators for efforts related to the Program. It is anticipated that through the combined efforts of the Core Director (Simon), Mr. Riley, and Ms. Podewils, the research effort of the P01 will run with optimum efficiency.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA104838-10
Application #
8539280
Study Section
Special Emphasis Panel (ZCA1-RPRB-O)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
10
Fiscal Year
2013
Total Cost
$65,782
Indirect Cost
$24,223

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Ochocki, Joshua D; Khare, Sanika; Hess, Markus et al. (2018) Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. Cell Metab 27:1263-1280.e6
Xie, Hong; Tang, Chih-Hang Anthony; Song, Jun H et al. (2018) IRE1? RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. J Clin Invest 128:1300-1316
Ackerman, Daniel; Tumanov, Sergey; Qiu, Bo et al. (2018) Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation. Cell Rep 24:2596-2605.e5
Sanchez, Danielle J; Steger, David J; Skuli, Nicolas et al. (2018) PPAR? is dispensable for clear cell renal cell carcinoma progression. Mol Metab 14:139-149
Li, Fuming; Lee, Kyoung Eun; Simon, M Celeste (2018) Detection of Hypoxia and HIF in Paraffin-Embedded Tumor Tissues. Methods Mol Biol 1742:277-282
Bansal, Ankita; Simon, M Celeste (2018) Glutathione metabolism in cancer progression and treatment resistance. J Cell Biol 217:2291-2298
Amirian, E Susan; Ostrom, Quinn T; Armstrong, Georgina N et al. (2018) Aspirin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-Analysis. Cancer Epidemiol Biomarkers Prev :
Davis, Jeremy L; Langan, Russell C; Panageas, Katherine S et al. (2017) Elevated Blood Neutrophil-to-Lymphocyte Ratio: A Readily Available Biomarker Associated with Death due to Disease in High Risk Nonmetastatic Melanoma. Ann Surg Oncol 24:1989-1996
Sands, Stephen; Ladas, Elena J; Kelly, Kara M et al. (2017) Glutamine for the treatment of vincristine-induced neuropathy in children and adolescents with cancer. Support Care Cancer 25:701-708
Zhang, Ji; Pavlova, Natalya N; Thompson, Craig B (2017) Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine. EMBO J 36:1302-1315

Showing the most recent 10 out of 123 publications