The Administrative Core will provide support for each of the Projects of this P01, as well as the Metabolism/Histopathology Core (Core B).
The aims of the Administrative Core are to ensure that the resources within the P01 are distributed equitably to the investigators and all rules and regulations of the National Cancer Institute and the National Institutes of Health are followed. The Administrative Core will coordinate monthly meetings of the investigators and their laboratories, and facilitate communication between our investigators and the External Advisory Board. The Administrative Core will also coordinate the quarterly regional meetings held at Princeton University and hosted by Dr. Joshua Rabinowitz. Finally, the Administrative Core will work with the business administration office of the Abramson Family Cancer Research Institute (AFCRI) to ensure that funds are subcontracted to Memorial Sloan-Kettering Cancer Center (MSKCC) for Project 1 led by Dr. Craig Thompson. The finances of the P01 will be organized by Mr. James Riley, the AFCRI Director of Fiscal Operations, who will meet monthly with the P01 PI and quarterly with each Project and Core Leader. Ms. Dana Opiela will coordinate travel arrangements for the members of the P01, as well as the advisors who will visit U. Pennsylvania. Furthermore, Ms. Jaclyn Regan will coordinate travel arrangements for the members of the P01 located at MSKCC. Both Ms. Opiela and Ms. Regan will provide administrative support for each of the P01 investigators for efforts related to the program. It is anticipated that through the combined efforts of the Core Director (Dr. Simon), Mr. Riley, Ms. Opiela, and Ms. Regan that the research effort of this P01 will run with optimum efficiency.

Public Health Relevance

As PI of this Program Project application, Dr. Celeste Simon will work closely with Ms. Dana Opiela, Administrative Assistant to this core. Moreover, Dr. Simon and Ms. Opiela will co-ordinate activities of the Program with Mr. Jim Riley, Director of Fiscal Operations at the Abramson Family Cancer Research Institute at the University of Pennsylvania, and Ms. Jaclyn Regan, laboratory Administrative Assistant to Drs. Craig Thompson and Tulia Lindsten at Memorial Sloan-Kettering Cancer Center.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-RPRB-J (M1))
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University of Pennsylvania
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Li, Bo; Qiu, Bo; Lee, David S M et al. (2014) Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513:251-5
Mathew, Lijoy K; Skuli, Nicolas; Mucaj, Vera et al. (2014) miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proc Natl Acad Sci U S A 111:291-6
Maas, Nancy L; Singh, Nickpreet; Diehl, J Alan (2014) Generation and characterization of an analog-sensitive PERK allele. Cancer Biol Ther 15:1106-11
Fan, Jing; Ye, Jiangbin; Kamphorst, Jurre J et al. (2014) Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510:298-302
Mathew, Lijoy K; Lee, Samuel S; Skuli, Nicolas et al. (2014) Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2* activity. Cancer Discov 4:53-60
Cheong, Heesun; Wu, Junmin; Gonzales, Linda K et al. (2014) Analysis of a lung defect in autophagy-deficient mouse strains. Autophagy 10:45-56
Ye, Jiangbin; Fan, Jing; Venneti, Sriram et al. (2014) Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov 4:1406-17
Ackerman, Daniel; Simon, M Celeste (2014) Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. Trends Cell Biol 24:472-8
Chitnis, Nilesh; Pytel, Dariusz; Diehl, J Alan (2013) UPR-inducible miRNAs contribute to stressful situations. Trends Biochem Sci 38:447-52
Wong, Waihay J; Qiu, Bo; Nakazawa, Michael S et al. (2013) MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death. Mol Cell Biol 33:3494-504

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