The Biostatistics and Data Management Core (BDMC Core B) of the MPD Research Consortium (MPD-RC) provides, statistical collaboration and data rnanagement and operations, support for .MPD-RC investigator initiated research and clinical projects through the combined expertises of the integrated Cores at NYU School of.Medicine (Judith D. Goldberg,Sc.D.) and the Consorzio Mario Negri Sud (Robterto Marchioli, M.D.). The collaboration allpvys .the integration of alMaboratpry.and clinjcal study data into the MPD-RC central database for integ rated, statistical analysis. In particular, state of the art statistical collaboration is provided forthe design, conduct, and analysis of translational research including clinical trials and laboratory studies to further the understanding of the causes and treatment of myelofibrosis and polycythemia vera. The Data Management component of the Core provides on line database and data entry systems and procedures and an infrastructure to facilitate communication among investigators and to facilitate the conduct of multicenter clinical and translational studies in these disease.

Public Health Relevance

The Biostatistics and Data Management Core of the MPD-RC provides collaboration in all phases of the research projects from study design through reporting to obtain meanlngful results from the multiple MPDRC research projects and programs using minimal patieint and animal resources. The user friendly web-based data management system facilitates data collection and management and collaborations across an international network of investigators conducting multicenter clinical trials and research programs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA108671-06
Application #
8377878
Study Section
Special Emphasis Panel (ZCA1-RPRB-J)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
6
Fiscal Year
2012
Total Cost
$760,257
Indirect Cost
$123,168
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Gilles, Laure; Arslan, Ahmet Dirim; Marinaccio, Christian et al. (2017) Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis. J Clin Invest 127:1316-1320
Varricchio, Lilian; Falchi, Mario; Dall'Ora, Massimiliano et al. (2017) Calreticulin: Challenges Posed by the Intrinsically Disordered Nature of Calreticulin to the Study of Its Function. Front Cell Dev Biol 5:96
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Falchi, Mario; Varricchio, Lilian; Martelli, Fabrizio et al. (2017) The Calreticulin control of human stress erythropoiesis is impaired by JAK2V617F in polycythemia vera. Exp Hematol 50:53-76
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