The Biostatistics and Data Management Core (BDMC Core B) of the MPD Research Consortium (MPD-RC) provides, statistical collaboration and data rnanagement and operations, support for .MPD-RC investigator initiated research and clinical projects through the combined expertises of the integrated Cores at NYU School of.Medicine (Judith D. Goldberg,Sc.D.) and the Consorzio Mario Negri Sud (Robterto Marchioli, M.D.). The collaboration allpvys .the integration of alMaboratpry.and clinjcal study data into the MPD-RC central database for integ rated, statistical analysis. In particular, state of the art statistical collaboration is provided forthe design, conduct, and analysis of translational research including clinical trials and laboratory studies to further the understanding of the causes and treatment of myelofibrosis and polycythemia vera. The Data Management component of the Core provides on line database and data entry systems and procedures and an infrastructure to facilitate communication among investigators and to facilitate the conduct of multicenter clinical and translational studies in these disease.

Public Health Relevance

The Biostatistics and Data Management Core of the MPD-RC provides collaboration in all phases of the research projects from study design through reporting to obtain meanlngful results from the multiple MPDRC research projects and programs using minimal patieint and animal resources. The user friendly web-based data management system facilitates data collection and management and collaborations across an international network of investigators conducting multicenter clinical trials and research programs.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1-RPRB-J)
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Icahn School of Medicine at Mount Sinai
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Gilles, Laure; Arslan, Ahmet Dirim; Marinaccio, Christian et al. (2017) Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis. J Clin Invest 127:1316-1320
Varricchio, Lilian; Falchi, Mario; Dall'Ora, Massimiliano et al. (2017) Calreticulin: Challenges Posed by the Intrinsically Disordered Nature of Calreticulin to the Study of Its Function. Front Cell Dev Biol 5:96
Zingariello, M; Sancillo, L; Martelli, F et al. (2017) The thrombopoietin/MPL axis is activated in the Gata1(low) mouse model of myelofibrosis and is associated with a defective RPS14 signature. Blood Cancer J 7:e572
Falchi, Mario; Varricchio, Lilian; Martelli, Fabrizio et al. (2017) The Calreticulin control of human stress erythropoiesis is impaired by JAK2V617F in polycythemia vera. Exp Hematol 50:53-76
Lanikova, Lucie; Reading, N Scott; Hu, Hao et al. (2017) Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer. Oncotarget 8:11739-11747
Sergueeva, Adelina; Miasnikova, Galina; Shah, Binal N et al. (2017) Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia. Haematologica 102:e166-e169
Wang, Linghua; Wheeler, David A; Prchal, Josef T (2016) Acquired uniparental disomy of chromosome 9p in hematologic malignancies. Exp Hematol 44:644-52
Klionsky, Daniel J (see original citation for additional authors) (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222
Migliaccio, Anna Rita (2016) To condition or not to condition-That is the question: The evolution of nonmyeloablative conditions for transplantation. Exp Hematol 44:706-12
Spangrude, Gerald J; Lewandowski, Daniel; Martelli, Fabrizio et al. (2016) P-Selectin Sustains Extramedullary Hematopoiesis in the Gata1 low Model of Myelofibrosis. Stem Cells 34:67-82

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