To improve therapeutic strategies, we propose to dissect primary (intrinsic) resistance of a given melanomato a panel of inhibitors with distinct modes of action. Our preliminary studies demonstrate that following agiven drug treatment, melanoma cells not only enter apoptosis and necrosis, but they can also respond viaone of two senescent phenotypes. These include either a

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA114046-06
Application #
8589630
Study Section
Special Emphasis Panel (ZCA1-RPRB-2 (M1))
Project Start
2005-04-01
Project End
2018-08-31
Budget Start
2013-09-25
Budget End
2014-08-31
Support Year
6
Fiscal Year
2013
Total Cost
$487,328
Indirect Cost
$155,922
Name
Wistar Institute
Department
Type
DUNS #
075524595
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Licciulli, Silvia; Maksimoska, Jasna; Zhou, Chun et al. (2013) FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem 288:29105-14
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