The Lung Pathology and Molecular Analysis Core (Core B) provides a powerful combination of experienced? and capable personnel whose primary role is to provide state of the art service and support to the research? investigators. To do this, the Core provides the technology and technical expertise to effectively supplement? the studies in lung cancer pathology, protein analysis, and microscopy described in this proposal. The major? objectives of this core are to (1) facilitate the acquisition, preservation, analysis, and dispersal of clinical? samples, (2) provide accurate histopathologic characterization of tumor tissues for all project investigators,? (3) allow access to state-of-the-art analytic protein chemistry and proteomics resources for use in the? identification, quantitation, and detailed structural characterization of proteins and protein complexes, and (4)? provide cutting-edge microscopy and imaging tools to ensure optimal visualization and analysis of cellular? processes. Specifically, Lung Pathology will develop and maintain a large repository of well-preserved, well-characterized? tissue specimens obtained from lung cancer patients that are receiving care or evaluation at? Emory University, or are participating in the Neoadjuvant Trial of Chemotherapy Hope (NATCH), to develop? unbiased comprehensive histologic characterization of the tissue samples used in each of the P-01 projects.? This Core also offers reliable centralized laboratory services to the investigators with respect to tissue? samples including state-of-the-art examination of immunohistochemical stains, in-situ hybridization microdissection,? and other techniques. It also serves as an important central database management resource to? maintain a comprehensive prospective, interactive database to provide access to patient demographic data? as well as detailed clinical pathologic data from patients with lung cancer. The protein analysis branch will? provide critical access to state-of-the-art analytical protein chemistry and proteomics resources for use in the? identification, quantitation, and detailed structural characterization of proteins and protein complexes as? needed. Lastly, the imaging facility will provide the necessary microscopy tools and technical expertise to? visualize the biological processes described in this application. Moreover, it will employ sophisticated image? analysis tools for image processing and accurate quantitative analyses. Taken together, the Lung Pathology? and Molecular Analysis Core serves as a critical resource that will facilitate scientific advancement through? lung pathology, protein-based initiatives, and microscopic analysis of cellular signaling pathways.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Subcommittee G - Education (NCI)
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Emory University
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Liu, Fakeng; Jin, Rui; Liu, Xiuju et al. (2016) LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions. Oncotarget 7:2519-31
Jin, Rui; Zhou, Wei (2016) TIF-IA: An oncogenic target of pre-ribosomal RNA synthesis. Biochim Biophys Acta 1866:189-196
Gilbert-Ross, Melissa; Marcus, Adam I; Zhou, Wei (2015) RhoA, a novel tumor suppressor or oncogene as a therapeutic target? Genes Dis 2:2-3
Feng, Xiuyan; Li, Zenggang; Du, Yuhong et al. (2015) Downregulation of urea transporter UT-A1 activity by 14-3-3 protein. Am J Physiol Renal Physiol 309:F71-8
Chen, Zhengjia; Yuan, Ying; Li, Zheng et al. (2015) Dose escalation with over-dose and under-dose controls in Phase I/II clinical trials. Contemp Clin Trials 43:133-41
Shi, Zhi; Park, Hae R; Du, Yuhong et al. (2015) Cables1 complex couples survival signaling to the cell death machinery. Cancer Res 75:147-58
Mao, Kaisheng; Liu, Fakeng; Liu, Xiuju et al. (2015) Re-expression of LKB1 in LKB1-mutant EKVX cells leads to resistance to paclitaxel through the up-regulation of MDR1 expression. Lung Cancer 88:131-8
Webber, Philip J; Park, Chanhee; Qui, Min et al. (2015) Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells. Oncoscience 2:765-76
Shi, Z; Li, Z; Li, Z J et al. (2015) Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3. Oncogene 34:2538-45
Chen, Zhengjia; Chen, Xinjia (2015) Rigorous Error Control Methods for Estimating Means of Bounded Random Variables. J Stat Plan Inference 157-158:54-76

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