The Director of the Administrative/Clinical Service Core (ACSC) will be Dr. Susan Chang. The ACSC will have 2 components, Administrative (led by Dr. Chang) and Clinical (led by Dr. Clarke). In addition. Dr. Sarah Nelson and Dr. Mitchel Berger will serve as co-investigators of the core to provide oversight of the projects planned. Dr. Chang is the Director of the Division of Neuro-Oncology and is the co-director of the administrative core of the prior PPG. She is experienced in the coordination of multiple projects and cores and has effectively provided the leadership for the successful activities of the previous cycle. She has demonstrated clear commitment to providing oversight of the PPG.
The specific aims of the ACSC are to provide Administrative and Clinical services to all 3 Projects to accomplish their Specific Aims and Research Plans. Administrative support will include fiscal, grants management and clerical support for annual progress reports and manuscript preparation, and organization for meetings between the Individual Projects key personnel, as well as for meetings with the External Advisory Board. All 3 Projects will involve patient research studies and the clinical component will provide the infrastructure and personnel to allow the conduct of non-therapeutic and therapeutic research studies. This will include clinical scientists, neurosurgeons, research nurses and clinical research assistants, as well as clinical space to obtain informed consent, treat, and follow patients enrolled in clinical studies within all the Projects. The overall goal of the ACSC will be to facilitate the interactions of the members of this PPG, provide clinical research support for each of the Projects, and administratively coordinate activities of the PPG membership. The following table depicts the distribution of effort provided to the 3 Projects by the 2 components of the ACSC. Component Project 1 Project 2 Project 3 Total Administrative 33.3% 33.3% 33.3% 100% Clinical 50% 20% 30% 100%

Public Health Relevance

This PPG consists of 3 highly integrated projects focused on determining the role of imaging and tissue correlates in the optimization of care for patients with glioblastoma (GBM). Each project will study patients with GBM and the ACSC will facilitate the successful completion of the research aims by providing administrative and clinical support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA118816-06A1
Application #
8589794
Study Section
Special Emphasis Panel (ZCA1-RPRB-2 (M1))
Project Start
2005-12-01
Project End
2018-07-31
Budget Start
2013-08-15
Budget End
2014-07-31
Support Year
6
Fiscal Year
2013
Total Cost
$212,045
Indirect Cost
$76,400
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Ohba, Shigeo; Mukherjee, Joydeep; See, Wendy L et al. (2014) Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance. Cancer Res 74:4836-44
Park, Ilwoo; Larson, Peder E Z; Tropp, James L et al. (2014) Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med 71:19-25
Elkhaled, Adam; Jalbert, Llewellyn; Constantin, Alexandra et al. (2014) Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy. NMR Biomed 27:578-93
Ahluwalia, Manmeet S; Chang, Susan M (2014) Medical therapy of gliomas. J Neurooncol 119:503-12
Lupo, Janine M; Nelson, Sarah J (2014) Advanced magnetic resonance imaging methods for planning and monitoring radiation therapy in patients with high-grade glioma. Semin Radiat Oncol 24:248-58
Park, Ilwoo; Mukherjee, Joydeep; Ito, Motokazu et al. (2014) Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res 74:7115-24
Rosenbluth, Kathryn Hammond; Gimenez, Francisco; Kells, Adrian P et al. (2013) Automated segmentation tool for brain infusions. PLoS One 8:e64452
Rosenbluth, Kathryn H; Martin, Alastair J; Mittermeyer, Stephan et al. (2013) Rapid inverse planning for pressure-driven drug infusions in the brain. PLoS One 8:e56397
Ozhinsky, Eugene; Vigneron, Daniel B; Chang, Susan M et al. (2013) Automated prescription of oblique brain 3D magnetic resonance spectroscopic imaging. Magn Reson Med 69:920-30
Constantin, Alexandra; Elkhaled, Adam; Jalbert, Llewellyn et al. (2012) Identifying malignant transformations in recurrent low grade gliomas using high resolution magic angle spinning spectroscopy. Artif Intell Med 55:61-70

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