The purpose of this Core is to provide to all Projects of the P01 with the high degree of research and clincial imaging support required to facilitate the collection of image guided surgical specimens and the serial assessment of response to therapy. Core functions will include the development of new methods, translation and maintenance of technologies developed in the Projects from the current and upcoming cycles into the clinic. The Core will comprise experienced investigators with broad expertise and a proven track record in working together, as well as with their collaborators. There are five major aims: (1) To translate the advanced MR data acquisition protocols and pulse sequences developed in the current cycle of the P01 from research to clinical scanners and to provide ongoing maintenance for them in order to accommodate changes in clinical practice, as well as updates to the scanner hardware or software. (2) To develop and maintain post-processing capabilities for analysis, visualization and interpretation of the multi-parametric and multi-dimensional imaging examinations used in Projects 1, 2 and 3 with a special emphasis on providing consistent and reliable metrics to describe tumor heterogeneity and spatial extent. (3) To support the acquisition and analysis of pre-surgery imaging data, the selection of targets of interest and the collection of image guided tissue samples from patients with GBM so that tumor heterogeneity can be studied in the context of imaging, histological and genomic properties as required in Projects 1, 2 and 3. (4) To provide improved quantitative analysis methods that will facilitate the integration of physiologic and metabolic MR parameters into the current RANO criteria and hence provide a more reliable and consistent assessment of changes in tumor burden for patients with GBM who are participating in Projects 1 and 3. (5) To develop a multi-faceted, multi-layered, and multi-disciplinary database of GBM characteristics of information from histopathology, immunohistochemistry, genomics, animal models, physiologic and metabolic imaging, and clinical information to allow all Projects to perform a systematic analysis of their data.

Public Health Relevance

The Core will improve the management of patients with glioblastoma by working with the Research Project and other Cores to translate and integrate novel methods developed as part of the current and upcoming cycle of the P01 with the currnt standard of care. New algorithms and data processing strategies will be developed to define targets for obtaining image guided tissue samples and assess response to therapy..

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA118816-07
Application #
8738075
Study Section
Special Emphasis Panel (ZCA1-RPRB-2)
Project Start
2014-08-01
Project End
2018-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
7
Fiscal Year
2014
Total Cost
$251,724
Indirect Cost
$92,175
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Mazor, Tali; Chesnelong, Charles; Pankov, Aleksandr et al. (2017) Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A 114:10743-10748
Anwar, Mekhail; Molinaro, Annette M; Morin, Olivier et al. (2017) Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res 188:303-313
Venkatesan, Subramanian; Swanton, Charles; Taylor, Barry S et al. (2017) Treatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution. Cold Spring Harb Perspect Med 7:
Autry, Adam; Phillips, Joanna J; Maleschlijski, Stojan et al. (2017) Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol 10:895-903
Zou, Xiaowei; Hart, Blaine L; Mabray, Marc et al. (2017) Automated algorithm for counting microbleeds in patients with familial cerebral cavernous malformations. Neuroradiology 59:685-690
Hayes, Josie; Yu, Yao; Jalbert, Llewellyn E et al. (2017) Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas. Neuro Oncol :
Wahl, Michael; Anwar, Mekhail; Hess, Christopher P et al. (2017) Relationship between radiation dose and microbleed formation in patients with malignant glioma. Radiat Oncol 12:126
Campbell, Brittany B; Light, Nicholas; Fabrizio, David et al. (2017) Comprehensive Analysis of Hypermutation in Human Cancer. Cell 171:1042-1056.e10
Park, Ilwoo; von Morze, Cornelius; Lupo, Janine M et al. (2017) Investigating tumor perfusion by hyperpolarized 13 C MRI with comparison to conventional gadolinium contrast-enhanced MRI and pathology in orthotopic human GBM xenografts. Magn Reson Med 77:841-847
Fan, QiWen; Aksoy, Ozlem; Wong, Robyn A et al. (2017) A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell 31:424-435

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