The overall purpose of Core A is to provide administrative support to the projects and cores of the Program, which enable the Program as a whole to meet its scientific mission more efficiently and expeditiously. The Core achieves this by carrying out a number of specific functions that relieve PIs of administrative concerns and enhance the coordination of work within the Program and the productive interaction ofthe Program with the larger research community. These functions will include:
Aim 1 : To ensure that the work carried out under the auspices of this Program meet the requirements of the NCI and NIH Aim 2: To coordinate meetings among the Program investigators and their laboratories Aim 3: To provide financial accounting to the PI and Project Leaders of each project and core.
Aim 4 : To coordinate communication between the investigators of the Program and Scientific Advisory Board.
Aim 5 : To coordinate travel related to the Program for the investigators and facilitate submission of manuscripts emanating from Program activities.
Aim 6 : To communicate the work emanating from our Program to the wider scientific community.

Public Health Relevance

The Administration Core plays an essential support role for all of the scientific projects of the Program, which are focused on understanding how Notch receptors are activated and turn on the expression of genes that drive the growth and survival of cancer cells. Thus, this shared resource is critical for the success of studies designed to elucidate fundannental aspects of how Notch signaling causes cancer, which in turn is likely to lead to new diagnostic approaches and therapies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA119070-06A1
Application #
8312785
Study Section
Special Emphasis Panel (ZCA1-RPRB-J (J1))
Project Start
2005-12-01
Project End
2017-06-30
Budget Start
2012-08-31
Budget End
2013-06-30
Support Year
6
Fiscal Year
2012
Total Cost
$39,393
Indirect Cost
$17,326
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Stein, Sarah J; Mack, Ethan A; Rome, Kelly S et al. (2016) Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. PLoS One 11:e0155408
Bernasconi-Elias, P; Hu, T; Jenkins, D et al. (2016) Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene 35:6077-6086
Chiang, Mark Y; Wang, Qing; Gormley, Anna C et al. (2016) High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia. Blood 128:2229-2240
Guo, Bingqian; McMillan, Brian J; Blacklow, Stephen C (2016) Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction. Curr Opin Struct Biol 41:38-45
McMillan, Brian J; Tibbe, Christine; Jeon, Hyesung et al. (2016) Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein. Cell Rep 16:1211-7
Xu, Xiang; Choi, Sung Hee; Hu, Tiancen et al. (2015) Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure 23:1227-35
McMillan, Brian J; Schnute, Björn; Ohlenhard, Nadja et al. (2015) A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases. Mol Cell 57:912-24
Wang, Hongfang; Zang, Chongzhi; Liu, X Shirley et al. (2015) The role of Notch receptors in transcriptional regulation. J Cell Physiol 230:982-8
Gordon, Wendy R; Zimmerman, Brandon; He, Li et al. (2015) Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. Dev Cell 33:729-36
Wang, Hongfang; Zang, Chongzhi; Taing, Len et al. (2014) NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A 111:705-10

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