Administrative Core. This administrative Core will have both scientific and organizational responsibilities. The scientific aspects will be carried out by Dr. Kwiatkowski. He will advise investigators on strategic and technical issues, promote collaboration and contact among projects, monitor the functions and effectiveness of the core facilities, and assess the scientific quality and progress of the work. This will require active interactions with all groups on a regular basis. Any scientific problems or organizational issues that arise will be discussed first with the co-PI, Dr. Cantley. There will also be an Internal Advisory Board composed of senior scientists in the Boston area, who will meet on an ad hoc basis to assist with any scientific or organizational issues. There will also be an External Advisory Board composed of senior scientists from outside Boston. There will be annual all-day meetings at which Project and Core Investigators will present research progress and plans to members of the Internal and External Advisory Board. Organizational aspects of the PPG will be handled by Dr. Kwiatkowski and the Administrative Coordinator, Robyn Naigles. She will organize all interactions among the projects and the cores, including arranging the annual meeting, and deal with all other administrative aspects including preparations of all progress reports and applications related to this PPG.
The overall goal of this program project application is to find treatments forthe hamartoma syndromes, and the common cancers in which these same genes (TSCl, TSC2, LKBI, PTEN) are involved. This administrative core sen/es a critical function in the administration and facilitation of this overall research program.
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|Menon, Suchithra; Dibble, Christian C; Talbott, George et al. (2014) Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell 156:771-85|
|Tchaicha, Jeremy H; Akbay, Esra A; Altabef, Abigail et al. (2014) Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Res 74:4676-84|
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|Guo, Y; Chirieac, L R; Bueno, R et al. (2014) Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma. Oncogene 33:3151-60|
|Tyburczy, Magdalena E; Wang, Ji-An; Li, Shaowei et al. (2014) Sun exposure causes somatic second-hit mutations and angiofibroma development in tuberous sclerosis complex. Hum Mol Genet 23:2023-9|
|González-Billalabeitia, Enrique; Seitzer, Nina; Song, Su Jung et al. (2014) Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. Cancer Discov 4:896-904|
|Kraus, Daniel; Yang, Qin; Kong, Dong et al. (2014) Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature 508:258-62|
|Yang, Ping; Cornejo, Kristine M; Sadow, Peter M et al. (2014) Renal cell carcinoma in tuberous sclerosis complex. Am J Surg Pathol 38:895-909|
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