The broad, long term objective of this project is to reduce morbidity and mortality caused by papillary thyroid carcinoma (PTC) which accounts for >80% of all thyroid cancers. PTC displays high heritability suggesting the existence of genes that when mutated predispose to PTC. So far no such inherited gene has been dentified. In preliminary experiments, linkage analysis in affected families has been used to discover several loci in the genome that likely harbor such genes. The first goal of this research is to refine the ocalization of these putative genes by linkage analysis and allelic association analysis using high-throughput technology. Once the loci have been narrowed to at most several megabases of DNA, positional cloning and mutation screening will be used to pinpoint the predisposing gene mutations. The discovery of genes predisposing to PTC would make it possible to predict who is, and who is not at high risk to develop PTC, allowing clinical screening and early detection, leading to public health benefits. Moreover, the elucidation of the genetic pathways leading to PTC allows therapeutic drugs and preventative strategies to be designed.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA124570-05
Application #
8378695
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
2013-04-29
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
5
Fiscal Year
2012
Total Cost
$276,251
Indirect Cost
$79,022
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
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