The broad, long term objective of this project is to reduce morbidity and mortality caused by papillary thyroid carcinoma (PTC) which accounts for >80% of all thyroid cancers. PTC displays high heritability suggesting the existence of genes that when mutated predispose to PTC. So far no such inherited gene has been dentified. In preliminary experiments, linkage analysis in affected families has been used to discover several loci in the genome that likely harbor such genes. The first goal of this research is to refine the ocalization of these putative genes by linkage analysis and allelic association analysis using high-throughput technology. Once the loci have been narrowed to at most several megabases of DNA, positional cloning and mutation screening will be used to pinpoint the predisposing gene mutations. The discovery of genes predisposing to PTC would make it possible to predict who is, and who is not at high risk to develop PTC, allowing clinical screening and early detection, leading to public health benefits. Moreover, the elucidation of the genetic pathways leading to PTC allows therapeutic drugs and preventative strategies to be designed.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA124570-05
Application #
8378695
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
2013-04-29
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
5
Fiscal Year
2012
Total Cost
$276,251
Indirect Cost
$79,022
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Yehia, Lamis; Jindal, Supriya; Komar, Anton A et al. (2018) Non-canonical role of cancer-associated mutant SEC23B in the ribosome biogenesis pathway. Hum Mol Genet 27:3154-3164
Chakedis, Jeffery; Shirley, Lawrence A; Terando, Alicia M et al. (2018) Identification of the Thoracic Duct Using Indocyanine Green During Cervical Lymphadenectomy. Ann Surg Oncol 25:3711-3717
Saporito, Donika; Brock, Pamela; Hampel, Heather et al. (2018) Penetrance of a rare familial mutation predisposing to papillary thyroid cancer. Fam Cancer 17:431-434
Segkos, Konstantinos; Porter, Kyle; Senter, Leigha et al. (2018) Neck Ultrasound in Patients with Follicular Thyroid Carcinoma. Horm Cancer 9:433-439
Kotlarek, Marta; Kubiak, Anna; Czetwerty?ska, Ma?gorzata et al. (2018) The rs2910164 Genetic Variant of miR-146a-3p Is Associated with Increased Overall Mortality in Patients with Follicular Variant Papillary Thyroid Carcinoma. Int J Mol Sci 19:
Russart, Kathryn L G; Huk, Danielle; Nelson, Randy J et al. (2018) Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion. Horm Behav 98:121-129
Ashtekar, Amruta; Huk, Danielle; Magner, Alexa et al. (2018) Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression. J Clin Endocrinol Metab 103:4135-4145
Smith, Iris Nira; Thacker, Stetson; Jaini, Ritika et al. (2018) Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes. J Biomol Struct Dyn :1-17
Feng, Fang; Yehia, Lamis; Ni, Ying et al. (2018) A Nonpump Function of Sodium Iodide Symporter in Thyroid Cancer via Cross-talk with PTEN Signaling. Cancer Res 78:6121-6133
Byrd, Victoria; Getz, Ted; Padmanabhan, Roshan et al. (2018) The microbiome in PTEN hamartoma tumor syndrome. Endocr Relat Cancer 25:233-243

Showing the most recent 10 out of 131 publications