The goal of the Integrated Clinical Information and Pathology Sample Repository Core (Core A) is to collect high quality clinical data and subject samples and provide a central repository for use in the scientific projects of this program project. Over the past 4 years we have successfully obtained biological samples from over 1200 individuals with differentiated thyroid cancer. Corresponding clinical, pathology and family history data have also been collected and entered into a relational database. These samples and data have been utilized by all 4 Projects of this program project and have led to multiple publications. For the next 5 years, the goal of Core A will be to expand and improve upon the currently existing data and biorepository in order to adequately meet the evolving needs of each of the projects. This includes (1) expanding and improving upon the existing thyroid cancer database;(2) expanding the current OSU thyroid cancer germline sample bank collection of biological samples (DNA, RNA, plasma and lymphoblastoid cultures);and (3) expanding upon the current OSU thyroid cancer tissue bank by collecting additional fresh frozen and paraffin-embedded thyroid tissue (tumor and matching normal) and creating and characterizing several primary cultured thyroid follicular cell lines for use in studies proposed in the Projects ofthe P01.

Public Health Relevance

Core A is essential to ensure that all research activities in this POl utilizing human samples are provided with sound clinical and pathological information, that the data are efficiently and accurately managed, and that distribution of samples and data occurs in a reliable and timely manner.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA124570-06
Application #
8505998
Study Section
Special Emphasis Panel (ZCA1-RPRB-O (J1))
Project Start
Project End
Budget Start
2013-04-30
Budget End
2014-03-31
Support Year
6
Fiscal Year
2013
Total Cost
$311,320
Indirect Cost
$99,011
Name
Ohio State University
Department
Type
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Nabhan, Fadi; Ringel, Matthew D (2016) Thyroid nodules and cancer management guidelines: comparisons and controversies. Endocr Relat Cancer :
Shirley, Lawrence A; McCarty, Samantha; Yang, Ming-Chen et al. (2016) Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target. Surgery 159:163-70
Tomsic, Jerneja; Fultz, Rebecca; Liyanarachchi, Sandya et al. (2016) HABP2 G534E Variant in Papillary Thyroid Carcinoma. PLoS One 11:e0146315
Harshman, Sean W; Canella, Alessandro; Ciarlariello, Paul D et al. (2016) Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. J Proteomics 136:89-98
Kirschner, Lawrence S; Qamri, Zahida; Kari, Suresh et al. (2016) Mouse models of thyroid cancer: A 2015 update. Mol Cell Endocrinol 421:18-27
Justiniano, Steven E; McElroy, Joseph P; Yu, Lianbo et al. (2016) Genetic variants in thyroid cancer distant metastases. Endocr Relat Cancer 23:L33-6
Wang, Yanqiang; Li, Wei; Phay, John E et al. (2016) Primary Cell Culture Systems for Human Thyroid Studies. Thyroid 26:1131-40
Nagy, Rebecca; Ringel, Matthew D (2015) Genetic predisposition for nonmedullary thyroid cancer. Horm Cancer 6:13-20
Yehia, Lamis; Niazi, Farshad; Ni, Ying et al. (2015) Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer. Am J Hum Genet 97:661-76
Tomsic, Jerneja; He, Huiling; de la Chapelle, Albert (2015) HABP2 Mutation and Nonmedullary Thyroid Cancer. N Engl J Med 373:2086

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