The goal of the Integrated Clinical Information and Pathology Sample Repository Core (Core A) is to collect high quality clinical data and subject samples and provide a central repository for use in the scientific projects of this program project. Over the past 4 years we have successfully obtained biological samples from over 1200 individuals with differentiated thyroid cancer. Corresponding clinical, pathology and family history data have also been collected and entered into a relational database. These samples and data have been utilized by all 4 Projects of this program project and have led to multiple publications. For the next 5 years, the goal of Core A will be to expand and improve upon the currently existing data and biorepository in order to adequately meet the evolving needs of each of the projects. This includes (1) expanding and improving upon the existing thyroid cancer database;(2) expanding the current OSU thyroid cancer germline sample bank collection of biological samples (DNA, RNA, plasma and lymphoblastoid cultures);and (3) expanding upon the current OSU thyroid cancer tissue bank by collecting additional fresh frozen and paraffin-embedded thyroid tissue (tumor and matching normal) and creating and characterizing several primary cultured thyroid follicular cell lines for use in studies proposed in the Projects ofthe P01.

Public Health Relevance

Core A is essential to ensure that all research activities in this POl utilizing human samples are provided with sound clinical and pathological information, that the data are efficiently and accurately managed, and that distribution of samples and data occurs in a reliable and timely manner.

National Institute of Health (NIH)
Research Program Projects (P01)
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Special Emphasis Panel (ZCA1)
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Ohio State University
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Mahdi, Haider; Mester, Jessica L; Nizialek, Emily A et al. (2015) Germline PTEN, SDHB-D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden-like syndromes: an international, multicenter, prospective study. Cancer 121:688-96
Lakshmanan, Aparna; Doseff, Andrea I; Ringel, Matthew D et al. (2014) Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells. Thyroid 24:878-87
Wójcicka, Anna; Czetwerty?ska, Ma?gorzata; ?wierniak, Micha? et al. (2014) Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma. Genes Chromosomes Cancer 53:516-23
Pringle, Daphne R; Vasko, Vasily V; Yu, Lianbo et al. (2014) Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice. J Clin Endocrinol Metab 99:E804-12
McCarty, Samantha K; Saji, Motoyasu; Zhang, Xiaoli et al. (2014) BRAF activates and physically interacts with PAK to regulate cell motility. Endocr Relat Cancer 21:865-77
Lakshmanan, Aparna; Scarberry, Daniel; Shen, Daniel H et al. (2014) Modulation of sodium iodide symporter in thyroid cancer. Horm Cancer 5:363-73
Wojcicka, A; de la Chapelle, A; Jazdzewski, K (2014) MicroRNA-related sequence variations in human cancers. Hum Genet 133:463-9
Stechschulte, Lance A; Wuescher, Leah; Marino, Joseph S et al. (2014) Glucocorticoid receptor ? stimulates Akt1 growth pathway by attenuation of PTEN. J Biol Chem 289:17885-94
Ngeow, Joanne; Stanuch, Kim; Mester, Jessica L et al. (2014) Second malignant neoplasms in patients with Cowden syndrome with underlying germline PTEN mutations. J Clin Oncol 32:1818-24
Medici, Marco; Porcu, Eleonora; Pistis, Giorgio et al. (2014) Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genet 10:e1004123

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