The goal of the Integrated Clinical Information and Pathology Sample Repository Core (Core A) is to collect high quality clinical data and subject samples and provide a central repository for use in the scientific projects of this program project. Over the past 4 years we have successfully obtained biological samples from over 1200 individuals with differentiated thyroid cancer. Corresponding clinical, pathology and family history data have also been collected and entered into a relational database. These samples and data have been utilized by all 4 Projects of this program project and have led to multiple publications. For the next 5 years, the goal of Core A will be to expand and improve upon the currently existing data and biorepository in order to adequately meet the evolving needs of each of the projects. This includes (1) expanding and improving upon the existing thyroid cancer database;(2) expanding the current OSU thyroid cancer germline sample bank collection of biological samples (DNA, RNA, plasma and lymphoblastoid cultures);and (3) expanding upon the current OSU thyroid cancer tissue bank by collecting additional fresh frozen and paraffin-embedded thyroid tissue (tumor and matching normal) and creating and characterizing several primary cultured thyroid follicular cell lines for use in studies proposed in the Projects ofthe P01.

Public Health Relevance

Core A is essential to ensure that all research activities in this POl utilizing human samples are provided with sound clinical and pathological information, that the data are efficiently and accurately managed, and that distribution of samples and data occurs in a reliable and timely manner.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA124570-07
Application #
8697757
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
DUNS #
City
Columbus
State
OH
Country
United States
Zip Code
Yu, Wanfeng; Ni, Ying; Saji, Motoyasu et al. (2017) Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells. Hum Mol Genet 26:1365-1375
Gudmundsson, Julius; Thorleifsson, Gudmar; Sigurdsson, Jon K et al. (2017) A genome-wide association study yields five novel thyroid cancer risk loci. Nat Commun 8:14517
Azmat, Umal; Porter, Kyle; Senter, Leigha et al. (2017) Thyroglobulin Liquid Chromatography-Tandem Mass Spectrometry Has a Low Sensitivity for Detecting Structural Disease in Patients with Antithyroglobulin Antibodies. Thyroid 27:74-80
Chen, Hannah H; Händel, Norman; Ngeow, Joanne et al. (2017) Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol 139:607-620.e15
Rossfeld, Kara K; Justiniano, Steven E; Ding, Haiming et al. (2017) Biological Evaluation of a Fluorescent-Imaging Agent for Medullary Thyroid Cancer in an Orthotopic Model. J Clin Endocrinol Metab 102:3268-3277
Saporito, Donika; Brock, Pamela; Hampel, Heather et al. (2017) Penetrance of a rare familial mutation predisposing to papillary thyroid cancer. Fam Cancer :
Byrd, Victoria; Getz, Ted M; Padmanabhan, Roshan et al. (2017) Microbiome in PTEN hamartoma tumor syndrome. Endocr Relat Cancer :
Tomsic, Jerneja; Fultz, Rebecca; Liyanarachchi, Sandya et al. (2017) Variants in microRNA genes in familial papillary thyroid carcinoma. Oncotarget 8:6475-6482
Ni, Ying; Seballos, Spencer; Fletcher, Benjamin et al. (2017) Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma. Hum Mol Genet 26:243-257
Ashtekar, Amruta; Huk, Danielle; Magner, Alexa et al. (2017) Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype. Endocr Relat Cancer 24:579-591

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