Abstract

The broad, long term objective of this project is to reduce morbidity and mortality caused by papillary thyroid carcinoma (PTC) which accounts for - 80% of all thyroid cancer. PTC displays remarl

Public Health Relevance

At first the major benefit of finding predisposing genes is likely to relate to the insight they provide in our understanding of pathways of disease causation. Given the low penetrance of many or most of the genes, it is possible that they will have only a limited impact on diagnostics and risk assessment except in the case of familial PTC. For this Project, we are focused on high penetrance genes in families based on our prior results to dissect gene function and to evaluate further families using newer whole genome sequencing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA124570-10
Application #
9246459
Study Section
Special Emphasis Panel (ZCA1-RPRB-O)
Project Start
2008-03-01
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
10
Fiscal Year
2017
Total Cost
$362,573
Indirect Cost
$115,973

  Institution

Name
Ohio State University
Department
Type
Domestic Higher Education
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210

  Publications

Chakedis, Jeffery; Shirley, Lawrence A; Terando, Alicia M et al. (2018) Identification of the Thoracic Duct Using Indocyanine Green During Cervical Lymphadenectomy. Ann Surg Oncol 25:3711-3717
Saporito, Donika; Brock, Pamela; Hampel, Heather et al. (2018) Penetrance of a rare familial mutation predisposing to papillary thyroid cancer. Fam Cancer 17:431-434
Segkos, Konstantinos; Porter, Kyle; Senter, Leigha et al. (2018) Neck Ultrasound in Patients with Follicular Thyroid Carcinoma. Horm Cancer 9:433-439
Kotlarek, Marta; Kubiak, Anna; Czetwerty?ska, Ma?gorzata et al. (2018) The rs2910164 Genetic Variant of miR-146a-3p Is Associated with Increased Overall Mortality in Patients with Follicular Variant Papillary Thyroid Carcinoma. Int J Mol Sci 19:
Russart, Kathryn L G; Huk, Danielle; Nelson, Randy J et al. (2018) Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion. Horm Behav 98:121-129
Ashtekar, Amruta; Huk, Danielle; Magner, Alexa et al. (2018) Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression. J Clin Endocrinol Metab 103:4135-4145
Smith, Iris Nira; Thacker, Stetson; Jaini, Ritika et al. (2018) Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes. J Biomol Struct Dyn :1-17
Feng, Fang; Yehia, Lamis; Ni, Ying et al. (2018) A Nonpump Function of Sodium Iodide Symporter in Thyroid Cancer via Cross-talk with PTEN Signaling. Cancer Res 78:6121-6133
Byrd, Victoria; Getz, Ted; Padmanabhan, Roshan et al. (2018) The microbiome in PTEN hamartoma tumor syndrome. Endocr Relat Cancer 25:233-243
Yehia, Lamis; Jindal, Supriya; Komar, Anton A et al. (2018) Non-canonical role of cancer-associated mutant SEC23B in the ribosome biogenesis pathway. Hum Mol Genet 27:3154-3164

Showing the most recent 10 out of 131 publications