The Biostatistics &Data Management core for The University of Texas M. D. Anderson Cancer Center Program Project "Mechanisms of Symptoms of Multiple Myeloma and Its Therapy" will provide comprehensive support for the planning and conduct of research implemented under this program. This resource will provide guidance for hypothesis testing and refinement, experimental design, implementation of clinical trials, data collection and management, data analysis, and data modeling. It will provide statistical expertise required for the preparation of reports summarizing program achievements. This core will also support the development of innovative statistical methodology required for the analysis of multivariate mixed ordinal and continuous longitudinal data. This methodology will be based on hierarchical, joint longitudinal modeling of symptom response and neuropsychiatric, neurocognitive, and quantitative sensory variables as functions of an underlying state space. The framework developed as part of this research program will facilitate the analysis of missing data and joint modeling of both continuous and discrete data. Finally, this core will support the development, analysis, and interpretation of psychometric instruments designed for the measurement of cancer symptoms and treatment-related symptom burden, and will apply multidimensional scaling and clustering methodology to identify groups of symptoms that occur concurrently with changes in cytokine-immunological activations. The specific, primary objectives of this core are as follows: 1. To develop appropriate statistical models for the analysis of data collected under each of the program projects. 2. To develop and maintain a central database management system for integrating data across all projects and cores. 3. To provide descriptive analysis, hypothesis testing, estimation, and innovative statistical modeling needed by the projects, developmental projects, and other cores to achieve their objectives. 4. To ensure that the results of all projects are based on well-designed experiments and that the results from these experiments are appropriately interpreted.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA124787-05
Application #
8381068
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$263,781
Indirect Cost
$89,010
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Shah, Nina; Shi, Qiuling; Williams, Loretta A et al. (2016) Higher Stem Cell Dose Infusion after Intensive Chemotherapy Does Not Improve Symptom Burden in Older Patients with Multiple Myeloma and Amyloidosis. Biol Blood Marrow Transplant 22:226-31
Xu, Yichen; Chen, Yanzhi; Li, Pingping et al. (2015) Ren Shen Yangrong Tang for Fatigue in Cancer Survivors: A Phase I/II Open-Label Study. J Altern Complement Med 21:281-7
Mendoza, Tito R; Wang, Xin Shelley; Williams, Loretta A et al. (2015) Measuring Therapy-Induced Peripheral Neuropathy: Preliminary Development and Validation of the Treatment-Induced Neuropathy Assessment Scale. J Pain 16:1032-43
Colvin, L A; Dougherty, P M (2015) Peripheral neuropathic pain: signs, symptoms, mechanisms, and causes: are they linked? Br J Anaesth 114:361-3
Robinson, C R; Dougherty, P M (2015) Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy. Neuroscience 285:1-10
Shi, Qiuling; Wang, Xin Shelley; Li, Guojun et al. (2015) Racial/ethnic disparities in inflammatory gene single-nucleotide polymorphisms as predictors of a high risk for symptom burden in patients with multiple myeloma 1 year after diagnosis. Cancer 121:1138-46
Gunn, G Brandon; Hansen, Chase C; Garden, Adam S et al. (2015) Favorable patient reported outcomes following IMRT for early carcinomas of the tonsillar fossa: Results from a symptom assessment study. Radiother Oncol 117:132-8
Wang, Xin Shelley; Shi, Qiuling; Williams, Loretta A et al. (2015) Longitudinal analysis of patient-reported symptoms post-autologous stem cell transplant and their relationship to inflammation in patients with multiple myeloma. Leuk Lymphoma 56:1335-41
Robinson, Caleb R; Zhang, Hongmei; Dougherty, Patrick M (2014) Altered discharges of spinal neurons parallel the behavioral phenotype shown by rats with bortezomib related chemotherapy induced peripheral neuropathy. Brain Res 1574:6-13
Zhang, Haijun; Dougherty, Patrick M (2014) Enhanced excitability of primary sensory neurons and altered gene expression of neuronal ion channels in dorsal root ganglion in paclitaxel-induced peripheral neuropathy. Anesthesiology 120:1463-75

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