The goal of the Administrative Core is to provide leadership, scientific exchange and administrative support to scientists and staff of this program project. The organizational activities include weekly laboratory data meetings, monthly laboratory data meetings and journal clubs, monthly laboratory seminars, monthly program projects leaders'meetings and annual reviews with the external advisory board members. The administrative core disseminates information to investigators regarding lectures of visiting scientists and educational activities in the Department and in the Lombard/ Comprehesive Cancer Center (LCCC). The Administrative Core also supports a Biostatistical Program which assists members in clinical and basic research study design, data analysis, and database management. Administrative oversight includes assurance of compliance with regulatory agencies, as it pertains to the institutional review board, the clinical research committee of the LCCC as well as the various environmental and safety related agencies. The administrative core component maintains the appropriate records and prepares the necessary reports. With input from the external advisory board and the committee of project leaders, the PI makes decisions regarding research directions and appropriateness of research allocations. In summary, the administrative core allows for the smooth operation of the research program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA130821-06
Application #
8744880
Study Section
Special Emphasis Panel (ZCA1-RPRB-O (M1))
Project Start
2013-09-01
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
6
Fiscal Year
2013
Total Cost
$81,241
Indirect Cost
$19,631
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Sun, Hongcheng; Tang, Huamei; Xie, Dacheng et al. (2016) Krüppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6. Clin Cancer Res 22:502-12
Yan, Jun; Mitra, Abhisek; Hu, Jiemiao et al. (2016) Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. J Hepatol 64:1128-36
Perumal, Deepak; Kuo, Pei-Yu; Leshchenko, Violetta V et al. (2016) Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. Cancer Res 76:1225-36
Chen, Jian; Shukla, Vivek; Farci, Patrizia et al. (2016) Loss of the TGF-β Effector β2SP Promotes Genomic Instability. Hepatology :
Divakar, S K A; Ramana Reddy, M V; Cosenza, S C et al. (2016) Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. Leukemia 30:86-93
Chen, Jian; Raju, Gottumukkala S; Jogunoori, Wilma et al. (2016) Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas. PLoS One 11:e0153933
Katz, L H; Likhter, M; Jogunoori, W et al. (2016) TGF-β signaling in liver and gastrointestinal cancers. Cancer Lett 379:166-72
Chen, Jian; Yao, Zhi-Xing; Chen, Jiun-Sheng et al. (2016) TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest 126:527-42
Chen, Jian; Katz, Lior H; Muñoz, Nina M et al. (2016) Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-β/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation. Sci Rep 6:30217
Mitra, Abhisek; Mishra, Lopa; Li, Shulin (2015) EMT, CTCs and CSCs in tumor relapse and drug-resistance. Oncotarget 6:10697-711

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