In this P01, investigators involved in 4 of the largest studies of breast cancer in women of African ancestry (AA) are collaborating to combine research hypotheses, data, samples, and expertise, and to harness the expertise of additional scientists, to discover risk factors that predispose AA women to early-onset aggressive breast cancer. This ambitious collaboration will require extensive coordination for the P01 to be successful. Administrative Core A, led by the 3 P01 PIs, will ensure that the Program Project runs smoothly, that the Projects meet their timelines and aims, and that the Cores provide the necessary support for each of the Projects to be successful. The Core will coordinate all organizational aspects of the P01, including maintaining matrix communications among the investigators and key personnel in each of the Projects and Cores, planning and conducting regular In-person meetings of the P01 investigators and with the External Advisory Board, and fiscal management of the overall P01 and disbursement of subcontract funds. Importantly, the Core will be responsible for evaluating and monitoring productivity, executing deadlines, and mediating any issues or problems that may arise. Core A will be based primarily at Roswell Park Cancer Institute (RPCI), in close coordination with the other 2 PI institutions, Boston University (BU) and the University of North Carolina at Chapel Hill (UNC), and with Dr. Kolonel at the University of Hawaii. The Administrative Core will ensure that the scientific and fiscal management of the study is rigorous, and provide a resource for coordination of the research through the Projects and Cores. Core A is essential to maintain the continuity of the Program Project. Without the pooling of expertise and coordination of tasks and duties, there would be multiple instances of duplication by Projects.

Public Health Relevance

This Program Project will investigate genetic and modifiable risk factors for aggressive, early-onset breast cancer among U.S. women of African ancestry (AA). Because this team science Program includes many scientists from several institutions, extensive coordination and oversight is required. The Core will guide the science, actively promote interdisciplinary collaboration, evaluate progress and ensure timely completion of Project Specific Aims. Under the leadership of the Administrative Core, our Program Project team will conduct high quality research aimed at lowering the incidence of aggressive breast cancer among AA women.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA151135-01A1
Application #
8174237
Study Section
Special Emphasis Panel (ZCA1-GRB-S (M1))
Project Start
2011-08-01
Project End
2016-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
1
Fiscal Year
2011
Total Cost
$353,730
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
824771034
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Bertrand, Kimberly A; Gerlovin, Hanna; Bethea, Traci N et al. (2017) Pubertal growth and adult height in relation to breast cancer risk in African American women. Int J Cancer 141:2462-2470
Espinal, Allyson C; Buas, Matthew F; Wang, Dan et al. (2017) FOXA1 hypermethylation: link between parity and ER-negative breast cancer in African American women? Breast Cancer Res Treat 166:559-568
Charlot, Marjory; Castro-Webb, Nelsy; Bethea, Traci N et al. (2017) Diabetes and breast cancer mortality in Black women. Cancer Causes Control 28:61-67
Roberts, Michelle R; Sucheston-Campbell, Lara E; Zirpoli, Gary R et al. (2017) Single nucleotide variants in metastasis-related genes are associated with breast cancer risk, by lymph node involvement and estrogen receptor status, in women with European and African ancestry. Mol Carcinog 56:1000-1009
Khoury, Thaer; Zirpoli, Gary; Cohen, Stephanie M et al. (2017) Ki-67 Expression in Breast Cancer Tissue Microarrays: Assessing Tumor Heterogeneity, Concordance With Full Section, and Scoring Methods. Am J Clin Pathol 148:108-118
Feng, Ye; Rhie, Suhn Kyong; Huo, Dezheng et al. (2017) Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry. Cancer Epidemiol Biomarkers Prev 26:1016-1026
Bertrand, Kimberly A; Bethea, Traci N; Adams-Campbell, Lucile L et al. (2017) Differential Patterns of Risk Factors for Early-Onset Breast Cancer by ER Status in African American Women. Cancer Epidemiol Biomarkers Prev 26:270-277
Williams, Lindsay A; Olshan, Andrew F; Hong, Chi-Chen et al. (2017) Alcohol Intake and Breast Cancer Risk in African American Women from the AMBER Consortium. Cancer Epidemiol Biomarkers Prev 26:787-794
Allott, Emma H; Cohen, Stephanie M; Geradts, Joseph et al. (2016) Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev 25:470-8
Yao, Song; Haddad, Stephen A; Hu, Qiang et al. (2016) Genetic variations in vitamin D-related pathways and breast cancer risk in African American women in the AMBER consortium. Int J Cancer 138:2118-26

Showing the most recent 10 out of 54 publications