In this P01, we will pool data, samples and expertise from 4 of the largest studies of breast cancer in AA women, the Carolina Breast Cancer Study (CBCS), the Women's Circle of Health Study (WCHS), the Black Women's Health Study (BWHS), and the Multi-Ethnic Cohort (MEC). We will continue case accruals, enrolling an additional 1000 AA women with breast cancer in CBCS and 1000 cases in WCHS and ascertainment of additional cases in BWHS and MEC, for a final sample size of more than 5,500 cases and 5,500 controls with DNA, providing sufficient power to conduct subtype analyses. Importantly, we will collect tumor tissue blocks from participants in the WCHS, CBCS and BWHS and, in collaboration with Core C, use immunohistochemistry (IHC) to identify breast cancer subtypes. This will allow us to pursue several hypotheses regarding the etiology of early aggressive breast cancer in AA women in the context of 4 independent, but interacting, projects. The success of the 4 scientific projects in this Program relies upon the successful activities of this proposed Core, to accrue and interview additional cases and to retrieve the tumor tissue blocks from the hospitals where participants in CBCS, WCHS and BWHS received their surgery. We have experience in these endeavors at each of our institutions, and the experiences of CBCS and WCHS in block collection will inform our efforts for BWHS through Core B.
The specific aims of this Core are to: 1) Conduct data collection (case ascertainment, contact with physicians and patients, interviews, DNA collection) in the WCHS and CBCS. Conduct collection of saliva samples from new breast cancer cases in the BWHS;and 2) Request, collect, and process tissue blocks and pathology reports for WCHS, CBCS and BWHS, using a unified systematic approach for all sites. This Core is essential for increasing the number of breast cancer cases available for use in all four projects of this POI, and for collection of tumor blocks in a coordinated fashion so that we can characteristic breast cancer subtypes and examine genetic and non-genetic risk factors for early, aggressive breast cancer.

Public Health Relevance

The Data Collection Core will coordinate continued ascertainment and recruitment of AA women with breast cancer for a final sample size large enough to be able to examine risk factors for early, aggressive breast cancer. Through collection of tumor blocks, we will be able to support all 4 Projects in the P01 to explore hypotheses for risk factors for early aggressive breast cancer in AA women, with adequate statistical power to make inferences that can be used for prevention of this often lethal disease in AA women. Our combined efforts will have an important impact on lowering the incidence of fatal breast cancers among AA women.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-GRB-S (M1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Roswell Park Cancer Institute Corp
United States
Zip Code
Bertrand, Kimberly A; Gerlovin, Hanna; Bethea, Traci N et al. (2017) Pubertal growth and adult height in relation to breast cancer risk in African American women. Int J Cancer 141:2462-2470
Espinal, Allyson C; Buas, Matthew F; Wang, Dan et al. (2017) FOXA1 hypermethylation: link between parity and ER-negative breast cancer in African American women? Breast Cancer Res Treat 166:559-568
Charlot, Marjory; Castro-Webb, Nelsy; Bethea, Traci N et al. (2017) Diabetes and breast cancer mortality in Black women. Cancer Causes Control 28:61-67
Roberts, Michelle R; Sucheston-Campbell, Lara E; Zirpoli, Gary R et al. (2017) Single nucleotide variants in metastasis-related genes are associated with breast cancer risk, by lymph node involvement and estrogen receptor status, in women with European and African ancestry. Mol Carcinog 56:1000-1009
Khoury, Thaer; Zirpoli, Gary; Cohen, Stephanie M et al. (2017) Ki-67 Expression in Breast Cancer Tissue Microarrays: Assessing Tumor Heterogeneity, Concordance With Full Section, and Scoring Methods. Am J Clin Pathol 148:108-118
Feng, Ye; Rhie, Suhn Kyong; Huo, Dezheng et al. (2017) Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry. Cancer Epidemiol Biomarkers Prev 26:1016-1026
Bertrand, Kimberly A; Bethea, Traci N; Adams-Campbell, Lucile L et al. (2017) Differential Patterns of Risk Factors for Early-Onset Breast Cancer by ER Status in African American Women. Cancer Epidemiol Biomarkers Prev 26:270-277
Williams, Lindsay A; Olshan, Andrew F; Hong, Chi-Chen et al. (2017) Alcohol Intake and Breast Cancer Risk in African American Women from the AMBER Consortium. Cancer Epidemiol Biomarkers Prev 26:787-794
Allott, Emma H; Cohen, Stephanie M; Geradts, Joseph et al. (2016) Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev 25:470-8
Yao, Song; Haddad, Stephen A; Hu, Qiang et al. (2016) Genetic variations in vitamin D-related pathways and breast cancer risk in African American women in the AMBER consortium. Int J Cancer 138:2118-26

Showing the most recent 10 out of 54 publications