The Biostatistics and Data management Core, Core D, will support all phases of data management and analyses in this P01 project. It will create and manage both old and new genetic, pathologic, and questionnaire data from the four participating studies. It will develop and maintain procedures for preparing and distributing datasets across studies using secure methods. It will collaborate with Cores B and C and Project Leaders in study design and sampling schemes for the various Projects. It will provide methodologic and analytic expertise to project investigators including study design, conduct of data analytic plans, bioinformatics analyses, and interpretation of statistical results. The Core will be responsible for data harmonization so that all investigators are using the same variable definitions. The Core will carry out many of the data analyses and has state-of-the-art hardware and software for doing so. The Core will collaborate closely with postdoctoral fellows and investigators on the individual Projects. The Leader of the Core and other Core investigators have expertise in genetics research and have had extensive experience in managing and analyzing the data of large multicenter studies. The activities of the Core will maintain high standards for data collection and analysis, maintain the integrity of the data, achieve consistency across the studies, and increase the productivity of Project investigators.
This Program Project is designed to identify causes of aggressive breast cancer in AA women. The results have the potential to lead to improved prevention and treatment. Core D will contribute to the efficiency, productivity, and quality of the Projects by supporting all phases of data management and analyses, maintaining high standards for data collection and analysis, and assuring consistency across studies and analyses.
|Chandran, Urmila; McCann, Susan E; Zirpoli, Gary et al. (2014) Intake of energy-dense foods, fast foods, sugary drinks, and breast cancer risk in African American and European American women. Nutr Cancer 66:1187-99|
|Robinson, Whitney R; Tse, Chiu Kit; Olshan, Andrew F et al. (2014) Body size across the life course and risk of premenopausal and postmenopausal breast cancer in Black women, the Carolina Breast Cancer Study, 1993-2001. Cancer Causes Control 25:1101-17|
|Chandwani, Sheenu; George, Prethibha A; Azu, Michelle et al. (2014) Role of preoperative magnetic resonance imaging in the surgical management of early-stage breast cancer. Ann Surg Oncol 21:3473-80|
|Quan, Lei; Gong, Zhihong; Yao, Song et al. (2014) Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry. Int J Cancer 134:1408-21|
|Ambrosone, Christine B; Zirpoli, Gary R; Bovbjerg, Dana Howard et al. (2014) Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women. Cancer Epidemiol Biomarkers Prev 23:1115-20|
|Ambrosone, Christine B; Zirpoli, Gary; Ruszczyk, Melanie et al. (2014) Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study. Cancer Causes Control 25:259-65|
|Palmer, Julie R; Ambrosone, Christine B; Olshan, Andrew F (2014) A collaborative study of the etiology of breast cancer subtypes in African American women: the AMBER consortium. Cancer Causes Control 25:309-19|
|Quan, Lei; Hong, Chi-Chen; Zirpoli, Gary et al. (2014) Variants of estrogen-related genes and breast cancer risk in European and African American women. Endocr Relat Cancer 21:853-64|
|Gong, Zhihong; Ambrosone, Christine B; McCann, Susan E et al. (2014) Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women. Int J Cancer 134:1422-35|
|Palmer, Julie R; Viscidi, Emma; Troester, Melissa A et al. (2014) Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER Consortium. J Natl Cancer Inst 106:|
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