PROJECT SUMIVIARY (See instructions): Shared Resource Core B. Clinical Support. James Vredenburgh, M.D., Core Director The Clinical Support Core provides a centralized resource to promote scientific and clinical research advances via interdisciplinary communication and collaboration across four key infrastructural components including biostatistics, informatics, neuropathology and immunomonltoring. Effective interaction within and across these four resource components will enable the successful clinical translation and implementation of novel therapeutic approaches against malignant brain tumors developed in Projects 1, 2 and 3 of this grant. Facilities and Equipment available among the four resource components of this Core are extensive and provide ample support to complete the studies and objectives outlined in this application. Similarly, methods and services available for this Core reflect the culmination of years of extensive research experience and acquired capabilities led by senior scientists and physician-scientists with a lengthy and productive history of interactive collaborations amongst each other as well as with the leaders of Projects 1, 2 and 3. The most compelling rationale for integrating the four key resource components of the Clinical Support Core into a centralized resource rather than including them separately for each project in this application is to optimize nterdisciplinary communication and effective interaction specifically regarding these critical support areas across the projects of this grant.
Our Specific Aims are: 1. To provide coordinated and systematic oversight and analysis during the design and conduct of the pre clinical and clinical studies outlined in this application in order to: a. Minimize toxicity and exposure of animals and humans to reagents being developed and tested in Projects 1, 2 and 3, and to maximize the usefulness of data obtained in this context; b. Integrate data generated during preclinical development with that from specimens analyzed during clinical trials outlined in Projects 1, 2 and 3 within the Nautilus and Oracle Clinical databases. 2. To provide integrated pathologic, histologic, immunohistochemical and molecular diagnostic studies for Projects 1, 2 and 3 which will be entered into the Biorepository Nautilus database and linked to the Oracle clinical database for each patient; 3. To provide comprehensive immunologic monitoring of patients enrolled in clinical trials in Projects 2 and 3 using highly standardized/validated state-of-the-art flow cytometry-based assays.
The Clinical Support Core will focus on seamlessly and efficiently integrating four key infrastructural resource components across the projects of this proposal, that include biostatistics, informatics, neuropathology and immunomonltoring. Effective interaction within and across these four resource components will enable the successful clinical translation, implementation and evaluation of novel therapeutic approaches against malignant brain tumors developed in Projects 1, 2 and 3 of this grant.
|Pruszynski, Marek; Koumarianou, Eftychia; Vaidyanathan, Ganesan et al. (2015) D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination. Nucl Med Biol 42:19-27|
|Koumarianou, Eftychia; Slastnikova, Tatiana A; Pruszynski, Marek et al. (2014) Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic. Nucl Med Biol 41:441-9|
|Killela, Patrick J; Pirozzi, Christopher J; Healy, Patrick et al. (2014) Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas. Oncotarget 5:1515-25|
|Pruszynski, Marek; Koumarianou, Eftychia; Vaidyanathan, Ganesan et al. (2014) Improved tumor targeting of anti-HER2 nanobody through N-succinimidyl 4-guanidinomethyl-3-iodobenzoate radiolabeling. J Nucl Med 55:650-6|
|Choi, Jaeyeon; Vaidyanathan, Ganesan; Koumarianou, Eftychia et al. (2014) N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: influence of isomeric substitution on radiolabeling and target cell residualization. Nucl Med Biol 41:802-12|
|Congdon, Kendra L; Gedeon, Patrick C; Suryadevara, Carter M et al. (2014) Epidermal growth factor receptor and variant III targeted immunotherapy. Neuro Oncol 16 Suppl 8:viii20-5|
|Choi, Bryan D; Gedeon, Patrick C; Kuan, Chien-Tsun et al. (2013) Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis. J Immunol Methods 395:14-20|
|Choi, Bryan D; Kuan, Chien-Tsun; Cai, Mingqing et al. (2013) Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma. Proc Natl Acad Sci U S A 110:270-5|
|Yang, Shicheng; Archer, Gary E; Flores, Catherine E et al. (2013) A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model. Cancer Immunol Immunother 62:1649-62|
|Pruszynski, Marek; Koumarianou, Eftychia; Vaidyanathan, Ganesan et al. (2013) Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody. Nucl Med Biol 40:52-9|
Showing the most recent 10 out of 11 publications