The role of the Administrative Core in this Program is to facilitate the science, manage all aspects of the finances, and provide oversight for compliance. As the Core Leader, Dr. Nishimura has established a group of External Advisors which consists of outstanding scientists with unique expertise in each area of the Program. This includes general tumor immunology, T cell biology, TCR gene transfer, autoimmunity against melanocytes, adoptive T cell transfer clinical trial and biostatistics. Also, he has assembled a group of internal advisors with specific scientific, program project, and administrative expertise to assist with the management ofthe Program. And finally, Dr. Nishimura has assembled an administrative staff with expertise in procurement, grants accounting/management, and compliance to manage the Program. These functions are essential to the smooth operation ofthe Program.

Public Health Relevance

This Core will provide administrative support for the entire Program. This includes facilitating the research, purchasing of supplies, accounting, compliance oversight, and general administrative assistance.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA154778-04
Application #
8745152
Study Section
Special Emphasis Panel (ZCA1-RPRB-J)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
$117,692
Indirect Cost
$69,829
Name
Loyola University Chicago
Department
Type
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153
Al-Hommrani, Mazen; Chakraborty, Paramita; Chatterjee, Shilpak et al. (2016) Dynamic Metabolism in Immune Response. J Immunol Res Ther 1:37-48
Spear, Timothy T; Nagato, Kaoru; Nishimura, Michael I (2016) Strategies to genetically engineer T cells for cancer immunotherapy. Cancer Immunol Immunother 65:631-49
Scheffel, Matthew J; Scurti, Gina; Simms, Patricia et al. (2016) Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death. Cancer Res 76:6006-6016
Blevins, Sydney J; Pierce, Brian G; Singh, Nishant K et al. (2016) How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire. Proc Natl Acad Sci U S A 113:E1276-85
Hellman, Lance M; Yin, Liusong; Wang, Yuan et al. (2016) Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes. J Immunol Methods 432:95-101
Banerjee, Anirban; Thyagarajan, Krishnamurthy; Chatterjee, Shilpak et al. (2016) Lack of p53 Augments Antitumor Functions in Cytolytic T Cells. Cancer Res 76:5229-40
Spear, Timothy T; Callender, Glenda G; Roszkowski, Jeffrey J et al. (2016) TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors. Cancer Immunol Immunother 65:293-304
Klarquist, Jared; Eby, Jonathan M; Henning, Steven W et al. (2016) Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin. Pigment Cell Melanoma Res 29:379-84
Spear, Timothy T; Riley, Timothy P; Lyons, Gretchen E et al. (2016) Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability. J Leukoc Biol 100:545-57
Rubinstein, Mark P; Su, Ee Wern; Suriano, Samantha et al. (2015) Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells. Cancer Immunol Immunother 64:539-49

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