The exciting potential for deep-seated brain tumors is the ability to treat them with focused ultrasound, without damage to the intervening tissues, and without the need to open the head. MRI can provide the necessary control for these procedures through outstanding soft tissue contrast for targeting, monitoring techniques with MR thermometry, and the means to assess tissue viability immediately after treatment.
The aims of this project are to improve these MR methods. Specifically, we aim to a) improve focal spot localization, b) improve temperature imaging including whole brain coverage and reduced sensitivity to artifacts, c) improved ablation in the presence of calcifications, and d) test the hypotheses that a series of ultrasound pulses do not damage brain tissue and that heat fixation occurs for temperatures greater than 60?C. In addition, we will investigate the appearance of thermal lesions on DWI, MT, T1, CE, and stiffness weighted images.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA159992-04
Application #
8728146
Study Section
Special Emphasis Panel (ZCA1-GRB-P)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
$188,400
Indirect Cost
$62,200
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Johnson, Ethan M; Vyas, Urvi; Ghanouni, Pejman et al. (2016) Improved cortical bone specificity in UTE MR Imaging. Magn Reson Med :
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Ghanouni, Pejman; Dobrotwir, Andrew; Bazzocchi, Alberto et al. (2016) Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study. Eur Radiol :
Bitton, Rachel R; Webb, Taylor D; Pauly, Kim Butts et al. (2016) Improving thermal dose accuracy in magnetic resonance-guided focused ultrasound surgery: Long-term thermometry using a prior baseline as a reference. J Magn Reson Imaging 43:181-9
Adams, Matthew S; Scott, Serena J; Salgaonkar, Vasant A et al. (2016) Thermal therapy of pancreatic tumours using endoluminal ultrasound: Parametric and patient-specific modelling. Int J Hyperthermia 32:97-111

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