. One critical function of the Administrative Core is the scheduling of and planning arrangements for meetings and research symposia involving the student and faculty participants. Regularly scheduled symposia involving members of the Vanderbilt University and OHSU groups and Dr. Turesky represent an essential feature of this program project. These will alternate between Vanderbilt University and at OHSU. An active External Advisory Board, the members of which are internationally recognized scientists, will meet regularly with us, evaluating progress and providing advice with regard to future research directions. This core will monitor the processing of orders, encumbering the proper sub-accounts for orders, and will confirm that orders have been received. It will confirm the accuracy of University accounting records, will file paperwork associated with internal requisitions, will monitor payroll records and hiring associated with the Program Project and will monitor the OHSU sub-contract, and Dr. Turesky's sub-contract. All of this is relatively complex in a grant subdivided into individual project accounts and with two sub-contracts, and located in three states. A primary function of the Administrative Core will be to work with and assemble data and reports involving teams of investigators from the Vanderbilt University College of Arts and Science, the Vanderbilt University Medical Center, the Oregon Health &Science University, and the Wadsworth Institute of the New York State Department of Health. The core will be centrally involved in the preparation of annual technical progress reports associated with this Program Project. In this capacity, it will serve all three projects and the DNA Core Lab equally. It will also assist with preparing manuscripts, correspondence, preparing slides and posters, maintaining bibliographies, etc., associated specifically with this Program Project.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA160032-21A1
Application #
8369646
Study Section
Special Emphasis Panel (ZCA1-RPRB-O (M1))
Project Start
1997-08-01
Project End
2017-07-31
Budget Start
2012-09-20
Budget End
2013-07-31
Support Year
21
Fiscal Year
2012
Total Cost
$25,882
Indirect Cost
$6,172
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Patra, Amritraj; Politica, Dustin A; Chatterjee, Arindom et al. (2016) Mechanism of Error-Free Bypass of the Environmental Carcinogen N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase η. Chembiochem 17:2033-2037
O'Flaherty, D K; Patra, A; Su, Y et al. (2016) Lesion Orientation of O(4)-Alkylthymidine Influences Replication by Human DNA Polymerase η. Chem Sci 7:4896-4904
Choi, Jeong-Yun; Patra, Amritaj; Yeom, Mina et al. (2016) Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι. J Biol Chem 291:21063-21073
Egli, Martin (2016) Diffraction Techniques in Structural Biology. Curr Protoc Nucleic Acid Chem 65:7.13.1-7.13.41
Minko, Irina G; Jacobs, Aaron C; de Leon, Arnie R et al. (2016) Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites. Sci Rep 6:28894
Patra, Amritraj; Su, Yan; Zhang, Qianqian et al. (2016) Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η. J Biol Chem 291:14134-45
Su, Yan; Egli, Martin; Guengerich, F Peter (2016) Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η. J Biol Chem 291:3747-56
Thiaville, Jennifer J; Kellner, Stefanie M; Yuan, Yifeng et al. (2016) Novel genomic island modifies DNA with 7-deazaguanine derivatives. Proc Natl Acad Sci U S A 113:E1452-9
Patra, Amitraj; Zhang, Qianqian; Guengerich, F Peter et al. (2016) Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase η. J Biol Chem 291:24304-24313
O'Flaherty, Derek K; Guengerich, F Peter; Egli, Martin et al. (2015) Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA. Biochemistry 54:7449-56

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