Core C - The Administrative Core will serve to coordinate administrative interactions between the different projects, their leadership, and scientists within the PPG, in order to facilitate the successful accomplishment of the scientific goals. This Core will oversee the facilitation and organization of regular meetings of the Steering Committee (Project and Core Leaders). Agendas for these meetings will include review of progress on the overall goals of the PPG. The reviews will also include assessments of the logistics of all interactions between Projects and Cores in order to identify any potential bottlenecks in transfer of specimens, data, protocols, funds, or other items. The Project and Core Leaders will also review expenditures and allocations of resources for all Projects and Cores at least twice per year. Reports from the external and internal scientific advisory boards will be collated and reviewed by the Project and Core Leaders following each annual PPG annual review, which will occur during the annual retreat. The administrative core will oversee collection and collation of annual reports from all Project and Core Leaders and compiling it into the annual progress report to NIH. The PI of this PPG, along with the Program Administrator, will assure smooth operation of the scientific agenda of the program project. The Administrative Core will organize all aspects of the annual retreat, which will include Project and Core Leaders, Co-Leaders and their laboratory staffs, and Scientific Advisory Board Members. The Administrative Core will oversee the launch and maintenance of a Web page for this PPG will allow distribution of findings among the global community, while enabling sharing protocols, reagents as well as information among the projects in real time.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
4P01CA163222-04
Application #
9022430
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2016-03-01
Budget End
2017-02-28
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
Romano, Gabriele; Chen, Pei-Ling; Song, Ping et al. (2018) A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling. Cancer Discov 8:556-567
Wein, Marc N; Foretz, Marc; Fisher, David E et al. (2018) Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab 29:723-735
Levy, Carmit; Golan, Tamar; Fisher, David E (2018) miRNA-211 stops the clock. Noncoding RNA Investig 2:
Eliades, Philip; Abraham, Brian J; Ji, Zhenyu et al. (2018) High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma. J Invest Dermatol 138:1582-1590
Nguyen, Nhu T; Fisher, David E (2018) MITF and UV responses in skin: From pigmentation to addiction. Pigment Cell Melanoma Res :
Kapp, Friedrich G; Perlin, Julie R; Hagedorn, Elliott J et al. (2018) Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature 558:445-448
Byrne, Elizabeth H; Fisher, David E (2017) Immune and molecular correlates in melanoma treated with immune checkpoint blockade. Cancer 123:2143-2153
Lin, William M; Fisher, David E (2017) Signaling and Immune Regulation in Melanoma Development and Responses to Therapy. Annu Rev Pathol 12:75-102
Kawakami, Akinori; Fisher, David E (2017) The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology. Lab Invest 97:649-656
Reuben, Alexandre; Spencer, Christine N; Prieto, Peter A et al. (2017) Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma. NPJ Genom Med 2:

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