Decision-making regarding breast cancer adjuvant chemotherapy in patients with favorable prognoses poses challenges for clinicians and patients alike given the relatively low marginal benefit of chemotherapy. Genomic profile assays in early stage, estrogen receptor-positive breast cancer refine estimates of both the risk of distant recurrence and the marginal benefit of chemotherapy over endocrine therapy alone and thereby enhance individualized care for patients with cancer. The benefits of the assay, however, will be realized only if the assay is used in the right patients and if receipt of chemotherapy is guided by assay results. The extent to which genomic profiling assays are used in practice and the impact of the assay results on receipt of chemotherapy in population-based patient samples are unknown.
The aims of this study are to investigate patient and clinician factors associated with the use of genomic profiles, specifically the 21-gene assay, and the impact of the assay on receipt of chemotherapy in at population-based sample. In addition, the study findings will inform innovative dissemination strategies of our research findings among oncologists. To achieve these aims, we will conduct a prospective population-based cohort study of 3,200 patients with early stage invasive, estrogen receptor-positive breast cancer and their treating oncologists (approximately 270) in the state-wide New Jersey and Georgia Surveillance, Epidemiology, and End Results (SEER) registries. Patients who are candidates for the genomic assay and their oncologists will be surveyed several months after diagnosis. Patient-reported variables, oncologist knowledge and attitudes elicited through vignettes, practice characteristics obtained from the oncologist survey, and SEER data will be merged to create a unique dataset. Multilevel analyses will incorporate consideration of patient, clinician, and practice influences on use of the assay and receipt of chemotherapy. The project aims will address critical barriers to our understanding of use and diffusion of tests-not only in breast cancer-^that promote individualized care and will ultimately help guide policies and interventions aimed at improving care.
Genomic assays of primary breast cancers can refine estimates of the risk of recurrence and the benefit of chemotherapy in patients with relatively favorable prognoses. This project, to be conducted in a large population-based sample of patients and their oncologists, will lay the foundation for understanding use of genomic assays and the receipt of treatment in response to genomic assays in breast and other cancers.
|Wallner, Lauren P; Li, Yun; McLeod, M Chandler et al. (2017) Decision-support networks of women newly diagnosed with breast cancer. Cancer 123:3895-3903|
|Taylor, Carolyn; Correa, Candace; Duane, Frances K et al. (2017) Estimating the Risks of Breast Cancer Radiotherapy: Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials. J Clin Oncol 35:1641-1649|
|Katz, Steven J; Wallner, Lauren P; Abrahamse, Paul H et al. (2017) Treatment experiences of Latinas after diagnosis of breast cancer. Cancer 123:3022-3030|
|Li, Yun; Kurian, Allison W; Bondarenko, Irina et al. (2017) The influence of 21-gene recurrence score assay on chemotherapy use in a population-based sample of breast cancer patients. Breast Cancer Res Treat 161:587-595|
|Hawley, Sarah T; Morris, Arden M (2017) Cultural challenges to engaging patients in shared decision making. Patient Educ Couns 100:18-24|
|Kurian, Allison W; Griffith, Kent A; Hamilton, Ann S et al. (2017) Genetic Testing and Counseling Among Patients With Newly Diagnosed Breast Cancer . JAMA 317:531-534|
|Katz, Steven J; Hawley, Sarah T; Bondarenko, Irina et al. (2017) Oncologists' influence on receipt of adjuvant chemotherapy: does it matter whom you see for treatment of curable breast cancer? Breast Cancer Res Treat 165:751-756|
|Hawley, Sarah T; Janz, Nancy K; Griffith, Kent A et al. (2017) Recurrence risk perception and quality of life following treatment of breast cancer. Breast Cancer Res Treat 161:557-565|
|Jagsi, Reshma; Hawley, Sarah T; Griffith, Kent A et al. (2017) Contralateral Prophylactic Mastectomy Decisions in a Population-Based Sample of Patients With Early-Stage Breast Cancer. JAMA Surg 152:274-282|
|Katz, Steven J; Janz, Nancy K; Abrahamse, Paul et al. (2017) Patient Reactions to Surgeon Recommendations About Contralateral Prophylactic Mastectomy for Treatment of Breast Cancer. JAMA Surg 152:658-664|
Showing the most recent 10 out of 32 publications