Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA165997-01A1
Application #
8596402
Study Section
Special Emphasis Panel (ZCA1-RPRB-B (M2))
Project Start
2013-09-18
Project End
2018-08-31
Budget Start
2013-09-18
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$71,870
Indirect Cost
$23,982
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Bu, Yiwen; Diehl, J Alan (2016) PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development. J Cell Physiol 231:2088-96
Xia, Chuan; Vijayan, Madhuvanthi; Pritzl, Curtis J et al. (2016) Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1. J Virol 90:2403-17
Gui, Jun; Gober, Michael; Yang, Xiaoping et al. (2016) Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation. J Invest Dermatol 136:1990-2002
Zhang, Kangjian; Yin, Xiao-Fei; Yang, Yuan-Qin et al. (2016) A potent in vivo anti-tumor efficacy of novel recombinant type I interferon. Clin Cancer Res :
Xu, Zhenhua; Bu, Yiwen; Chitnis, Nilesh et al. (2016) miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun 7:11422
Katlinskaya, Yuliya V; Katlinski, Kanstantsin V; Yu, Qiujing et al. (2016) Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. Cell Rep 15:171-80
Bu, Yiwen; Diehl, J Alan (2016) Stressing out melanoma with an anti-GRP78 compound. Pigment Cell Melanoma Res 29:490-1
Katlinskaya, Yuliya V; Katlinski, Kanstantsin V; Lasri, Audrey et al. (2016) Type I Interferons Control Proliferation and Function of the Intestinal Epithelium. Mol Cell Biol 36:1124-35
Davar, Diwakar; Fuchs, Serge Y; Kirkwood, John M (2016) BRAF Inhibitors and IFNα: Plus, Minus, or Indeterminate? J Natl Cancer Inst 108:
Yu, Qiujing; Zhao, Bin; Gui, Jun et al. (2015) Type I interferons mediate pancreatic toxicities of PERK inhibition. Proc Natl Acad Sci U S A 112:15420-5

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