The administrative core manages the overall organization of the project, and is responsible for project progress and budgetary reporting to NIH through annual progress reports and other mechanisms. The purposes of the administrative core are to coordinate the efforts of the individual groups, fostering communication and cooperation, and to ensure equitable access of each project to the shared resources provided by the virology core. To this end, the administrative core organizes monthly meetings of the project team where scientific progress is reported and other business discussed. This core also maintains an electronic bulletin board for the groups, which facilitates and enhances communication among project participants. Papers submitted for publication by project leaders are also distributed among the members of the project on a regular basis through the administrative core, providing a mechanism for team input. This core also organizes the annual review of the overall project by the advisory committees.

Public Health Relevance

The administrative core organizes a research project involving multidisciplinary team of investigators to address fundamental questions in 'novel immune mechanisms against herpes viruses. The knowledge gained by these research projects is relevant to the prevention and control of human herpesviruses.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA177322-01A1
Application #
8660817
Study Section
Special Emphasis Panel (ZCA1-RPRB-J (O1))
Project Start
2014-09-19
Project End
2019-08-31
Budget Start
2014-09-19
Budget End
2015-08-31
Support Year
1
Fiscal Year
2014
Total Cost
$90,208
Indirect Cost
$10,147
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Šedý, John R; Balmert, M Olivia; Ware, Brian C et al. (2017) A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator. J Biol Chem 292:21060-21070
Yau, Edwin H; Kummetha, Indrasena Reddy; Lichinchi, Gianluigi et al. (2017) Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Cancer Res 77:6330-6339
Gong, Danyang; Dai, Xinghong; Xiao, Yuchen et al. (2017) Virus-Like Vesicles of Kaposi's Sarcoma-Associated Herpesvirus Activate Lytic Replication by Triggering Differentiation Signaling. J Virol 91:
Du, Yushen; Chi, Xiumei; Wang, Chong et al. (2017) Quantifying perinatal transmission of Hepatitis B viral quasispecies by tag linkage deep sequencing. Sci Rep 7:10168
Du, Yushen; Zhang, Tian-Hao; Dai, Lei et al. (2017) Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. MBio 8:
Dai, Xinghong; Li, Zhihai; Lai, Mason et al. (2017) In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus. Nature 541:112-116
Xiong, Xiao-Peng; Kurthkoti, Krishna; Chang, Kung-Yen et al. (2016) miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila. PLoS Pathog 12:e1006034
Gong, Danyang; Kim, Yong Hoon; Xiao, Yuchen et al. (2016) A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export. Cell Host Microbe 20:642-653
Du, Yushen; Wu, Nicholas C; Jiang, Lin et al. (2016) Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis. MBio 7:
Scarzello, Anthony J; Jiang, Qun; Back, Timothy et al. (2016) LT?R signalling preferentially accelerates oncogenic AKT-initiated liver tumours. Gut 65:1765-75

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