The Administrative Core serves a critical function for the Program Project, serving as the administrative arm and central focal point for organization and dissemination of scientific, budgetary, and other information which are associated with the Program Project. It also will coordinate all communication among the different groups that are involved in the Program Project. Manuscript preparations, slide presentations, etc. involving the Principal Investigator, correspondence, purchasing of supplies and services, arrangements for PPG meetings, photocopying and dissemination of information and presentations, purchasing of supplies and other things necessary for research, preparation and records of traveling to scientific meetings by the Program Project group, oversite of financial matters, maintenance and upkeep of data bases, and other administrative functions as needed will be coordinated by the Administrative Core. All correspondence, arrangements for outside scientific visitors related to the Program Project, coordination of activities with outside collaborators, and other related administrative functions will be coordinated by the Core. Finally, the Administrative Core provides the focal point for the extensive local collaborative efforts and cooperations which have marked the success of the Program Project in the past and into the future.

Public Health Relevance

There are still many unmet public health needs in the treatment of pain and drug abuse in our society and worldwide. In this research we will examine the design, synthesis, and biological evaluation of novel peptide and peptidomimetic ligands for the treatment of prolonged pain, especially neuropathic pain that will address new mechanism of pain control with minimal side effects, drug seeking behavior and tolerance.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA006284-22
Application #
8446518
Study Section
Human Development Research Subcommittee (NIDA)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
22
Fiscal Year
2013
Total Cost
$74,811
Indirect Cost
$25,431
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Lee, Yeon Sun; Remesic, Michael; Ramos-Colon, Cyf et al. (2016) Cyclic non-opioid dynorphin A analogues for the bradykinin receptors. Bioorg Med Chem Lett 26:5513-5516
Deekonda, Srinivas; Rankin, David; Davis, Peg et al. (2016) Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands. Bioorg Med Chem 24:85-91
Hall, Sara M; Lee, Yeon Sun; Hruby, Victor J (2016) Dynorphin A analogs for the treatment of chronic neuropathic pain. Future Med Chem 8:165-77
Deekonda, Srinivas; Cole, Jacob; Sunna, Sydney et al. (2016) Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. Bioorg Med Chem Lett 26:222-7
Lee, Yeon Sun; Kupp, Robert; Remesic, Michael V et al. (2016) Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors. Chem Biol Drug Des 88:615-9
Nair, Padma; Yamamoto, Takashi; Cowell, Scott et al. (2015) Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorg Med Chem Lett 25:3716-20
Cai, Minying; Marelli, Udaya Kiran; Bao, Jennifer et al. (2015) Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. J Med Chem 58:6359-67
Mehr-un-Nisa; Munawar, Munawar A; Lee, Yeon Sun et al. (2015) Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs. Bioorg Med Chem 23:1251-9
Giri, Aswini Kumar; Apostol, Christopher R; Wang, Yue et al. (2015) Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. J Med Chem 58:8573-83
Lee, Yeon Sun; Hall, Sara M; Ramos-Colon, Cyf et al. (2015) Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors Clin Investig 2:

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