The primary objective of the Administrative Core is to ensure the effective integration and interaction of the scientists and other personnel working on the Projects and Scientific Cores that comprise this PPG. First, the Core establishes the scientific priorities and directions of the research through regular meetings of the PPG's Executive Committee. Second, the Core is responsible for administering the day-to-day activities of the PPG, including the monitoring of all budgets, submission of progress reports, and adherence to regulatory requirements associated with our research. Third, the Core coordinates the many modes of communication among PPG investigators, including regular Webex meetings, videoconferences, and face-to-face visits that ensure our integrated research program. Likewise, the Core supports visits to New York and other sites by members of our External Advisory Committee, and key consultants, to meet with PPG faculty and trainees and review the progress of our research. Fourth, the Core maintains a creative PPG website to foster communication not only among PPG investigators, but also with the scientific community and general public at large. Such communication includes resource and data sharing and the dissemination of vast amounts of genome-wide chromatin and gene expression data as rapidly as possible as well as enabling the free download of novel PPG software designed to analyze complex datasets. Fifth, the Core fosters several additional outreach efforts to patient advocacy and community organizations. Sixth, the Core, through the Executive Committee, works to ensure the successful career paths of numerous junior faculty as well as students and postdoctoral trainees. We expect numerous individual R and K grants and NRSAs to continue to be generated by the PPG's research. Such career development focuses in particular on the recruitment and retention of women and minority scientists;we are proud of our track record in this regard. Seventh, the Core is responsible, in collaboration with our various training programs, to ensure the safe and ethical conduct of research. Joining together effectively to form a unified research team is key to the success of this large undertaking, and we are confident in our continued ability to accomplish this goal.

Public Health Relevance

Addiction remains one of the world's greatest public health problems, yet its pathophysiology remains incompletely understood and available treatments for addictions to various drugs of abuse are inadequately effective for most people. We believe that the most effective way of eventually developing definitive treatments and cures for addiction rests in part in a better understanding of its underlying neurobiology.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
2P01DA008227-22A1
Application #
8609278
Study Section
Special Emphasis Panel (ZRG1-IFCN-B (40))
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
22
Fiscal Year
2014
Total Cost
$68,649
Indirect Cost
$28,148
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Egervari, Gabor; Landry, Joseph; Callens, James et al. (2017) Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target. Biol Psychiatry 81:585-594
Sun, Linlin; Zhao, Jian-Yuan; Gu, Xiyao et al. (2017) Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons. Pain 158:1153-1165
Wells, Audrey M; Ridener, Elysia; Bourbonais, Clinton A et al. (2017) Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism. J Neurosci 37:7656-7668
Nugent, Alexandria L; Anderson, Ethan M; Larson, Erin B et al. (2017) Incubation of cue-induced reinstatement of cocaine, but not sucrose, seeking in C57BL/6J mice. Pharmacol Biochem Behav 159:12-17
Ceglia, Ilaria; Lee, Ko-Woon; Cahill, Michael E et al. (2017) WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. Proc Natl Acad Sci U S A 114:1395-1400
Loh, Yong-Hwee Eddie; Feng, Jian; Nestler, Eric et al. (2017) Bioinformatic Analysis for Profiling Drug-induced Chromatin Modification Landscapes in Mouse Brain Using ChlP-seq Data. Bio Protoc 7:
Anderson, Ethan M; Self, David W (2017) It's only a matter of time: longevity of cocaine-induced changes in dendritic spine density in the nucleus accumbens. Curr Opin Behav Sci 13:117-123
Miller, M L; Ren, Y; Szutorisz, H et al. (2017) Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. Mol Psychiatry :
Kozlenkov, Alexey; Jaffe, Andrew E; Timashpolsky, Alisa et al. (2017) DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age. Genes (Basel) 8:
Descalzi, Giannina; Mitsi, Vasiliki; Purushothaman, Immanuel et al. (2017) Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression. Sci Signal 10:

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