Why does this program need a communication/administration core? The original request for proposals (RFP) specifically mandated investigators at different institutions. Indeed, the RFP stipulated that the number of investigators from one institution could not exceed two. For this reason, the original proposal included R. Edwards, R.B. Kelly (both UCSF) and D. Sulzer (Columbia). We were forced to exclude M. von Zastrow (UCSF) because he would have been the third person at UCSF. Since these restrictions were dropped on resubmission, we added M. von Zastrow, but then replaced R.B. Kelly with T. Ryan (Cornell Med), and thus had two investigators in New York City as well as the two in San Francisco, With three independent institutions involved, and two different departments even at UCSF, the program has presented a significant challenge to communication and administration. Although we are now replacing T. Ryan with a UCSF-affiliated investigator, A. Kreitzer holds a position in the private Gladstone Institutes, and his project thus also requires an outside contract, with the associated complications.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA010154-17
Application #
8507693
Study Section
Special Emphasis Panel (ZRG1-MDCN-F)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
17
Fiscal Year
2013
Total Cost
$43,479
Indirect Cost
$15,770
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Irannejad, Roshanak; Kotowski, Sarah J; von Zastrow, Mark (2014) Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol 535:403-18
Tsvetanova, Nikoleta G; von Zastrow, Mark (2014) Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat Chem Biol 10:1061-5
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Karpowicz Jr, Richard J; Dunn, Matthew; Sulzer, David et al. (2013) APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter. ACS Chem Neurosci 4:858-69

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