The Technology Core will provide outstanding critical analytical support for all three projects of the current competitive renewal. By having a centralized resource to analyze the biogenic amines, metabolites, synthesizing enzymes, drug levels and their metabolites for this program, we will be able to substantially enhance efficiency, lower costs, and improve reliability across the projects. We employed a similar centralized approach with the previous grant and found that centralization of these technical services was extremely helpful and consequently we propose to maintain this strategy for the current proposal. This will be achieved through the Technology Core which will be associated with the Center for Human Toxicology (CHT) at the University of Utah under the direction of Dennis Crouch, a co-director for the CHT and director of the Technology Resource for most of the previous years 1-5 of this Program Project. The CHT is a nonprofit laboratory administratively located at the University of Utah College of Pharmacy. The CHT's mission objectives are methods development and analytical services in support of clinical and basic research in drug abuse and forensic toxicology. CHT is internationally recognized for its analytical capacity and frequently contracts with NIDA, other federal and private agencies as well as foundations and insurance companies for analytical services. Because of its unparalleled experience and state-of-the-art resources, the CHT is considered by many one of the leading analytical drug laboratories in the world. This outstanding resource will greatly strengthen this Program Project and assure highly accurate and efficient analytical services for all of the projects.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA013367-09
Application #
8223706
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
9
Fiscal Year
2011
Total Cost
$195,027
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
German, Christopher L; Gudheti, Manasa V; Fleckenstein, Annette E et al. (2017) Brain Slice Staining and Preparation for Three-Dimensional Super-Resolution Microscopy. Methods Mol Biol 1663:153-162
Fricks-Gleason, Ashley N; German, Christopher L; Hoonakker, Amanda J et al. (2016) An acute, epitope-specific modification in the dopamine transporter associated with methamphetamine-induced neurotoxicity. Synapse 70:139-46
McFadden, Lisa M; Vieira-Brock, Paula L; Hanson, Glen R et al. (2015) Prior methamphetamine self-administration attenuates the dopaminergic deficits caused by a subsequent methamphetamine exposure. Neuropharmacology 93:146-54
German, Christopher L; Baladi, Michelle G; McFadden, Lisa M et al. (2015) Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease. Pharmacol Rev 67:1005-24
Vieira-Brock, Paula L; McFadden, Lisa M; Nielsen, Shannon M et al. (2015) Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits. J Pharmacol Exp Ther 355:463-72
Alburges, Mario E; Hoonakker, Amanda J; Cordova, Nathaniel M et al. (2015) Effect of low doses of methamphetamine on rat limbic-related neurotensin systems. Synapse 69:396-404
Vieira-Brock, Paula L; McFadden, Lisa M; Nielsen, Shannon M et al. (2015) Nicotine Administration Attenuates Methamphetamine-Induced Novel Object Recognition Deficits. Int J Neuropsychopharmacol 18:
German, Christopher L; Fleckenstein, Annette E; Hanson, Glen R (2014) Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Sci 97:2-8
Baladi, Michelle G; Nielsen, Shannon M; Umpierre, Anthony et al. (2014) Prior methylphenidate self-administration alters the subsequent reinforcing effects of methamphetamine in rats. Behav Pharmacol 25:758-65
Baladi, Michelle G; Newman, Amy H; Nielsen, Shannon M et al. (2014) Dopamine D(3) receptors contribute to methamphetamine-induced alterations in dopaminergic neuronal function: role of hyperthermia. Eur J Pharmacol 732:105-10

Showing the most recent 10 out of 72 publications