The Core's mission is the scientific and administrative support of all four Projects in the Program, providing a standardized source of reagents, resources, and protocols. A Chemistry Component will design, synthesize, and test enzyme inhibitors for potency and selectivity in vitro and in vivo before passing them on to Projects 2 and 3/4 for co-crystallization studies and pharmacological analysis, respectively. A Biochemistry Component will provide pure proteins to Program Projects 1 and 2 for functional and structural studies, respectively. A Mouse Component will manage the breeding, crossing, and distribution of genetic mouse models. These three scientific arms of the Core will combine to provide the best and most consistent reagents for use in the research aims of the Program Project as a whole. Finally, a small Administrative Component will ensure fiscal responsibility, seamless communication, and proper documentation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA017259-09
Application #
8375145
Study Section
Human Development Research Subcommittee (NIDA)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$264,982
Indirect Cost
$125,931
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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Wiebelhaus, Jason M; Grim, Travis W; Owens, Robert A et al. (2015) Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice. J Pharmacol Exp Ther 352:195-207
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