Abstract

The primary function ofthe administrative core of this P01 application will be to facilitate generation of scientific knowledge by the four projects through efficient scientific progress, oversight and quality control of data, dissemination of this knowledge through publications, and conference presentations, training of graduate students and postdoctoral fellows, and, where applicable, translation of this new knowledge into clinical research. As indicated in the overview, the scientific focus of this application will be generation of new knowledge on """"""""Mechanisms of drug disposition during pregnancy."""""""" To accomplish the above stated primary function, the administrative core will have the following Specific Aims: 1. Ensure that the necessary administrative structure is in place for a) efficient scientific progress, oversight and quality control of data;b) collaboration and sharing of data within and among the projects;c) rapid publication and dissemination of data;and d) training of graduate students and postdoctoral fellows. 2. Ensure that appropriate administrative and fiscal oversight exists to allow attainment of goals stated in (1) above.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA032507-02
Application #
8726365
Study Section
Special Emphasis Panel (ZRG1-DKUS-C)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$77,062
Indirect Cost
$27,184

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Han, Lyrialle W; Gao, Chunying; Mao, Qingcheng (2018) An update on expression and function of P-gp/ABCB1 and BCRP/ABCG2 in the placenta and fetus. Expert Opin Drug Metab Toxicol 14:817-829
Patilea-Vrana, Gabriela I; Unadkat, Jashvant D (2018) When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions. Drug Metab Dispos 46:1487-1496
Kumar, Vineet; Yin, Jia; Billington, Sarah et al. (2018) The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance. Drug Metab Dispos 46:1441-1445
Neradugomma, Naveen K; Drafton, Kaitlyn; O'Day, Diana R et al. (2018) Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta. Placenta 66:36-39
Liao, Michael Z; Gao, Chunying; Phillips, Brian R et al. (2018) Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation. Drug Metab Dispos 46:100-108
Guo, Yingying; Chu, Xiaoyan; Parrott, Neil J et al. (2018) Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches. Clin Pharmacol Ther 104:865-889
Johnson, Emily J; González-Peréz, Vanessa; Tian, Dan-Dan et al. (2018) Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended Approach. Drug Metab Dispos 46:1046-1052
Grant, Kimberly S; Petroff, Rebekah; Isoherranen, Nina et al. (2018) Cannabis use during pregnancy: Pharmacokinetics and effects on child development. Pharmacol Ther 182:133-151
Wagner, David J; Shireman, Laura M; Ahn, Sojung et al. (2018) Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of Para-Hydroxymethamphetamine. Drug Metab Dispos 46:1277-1284
Wagner, David J; Sager, Jennifer E; Duan, Haichuan et al. (2017) Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters. Drug Metab Dispos 45:770-778

Showing the most recent 10 out of 29 publications