The purpose of the Administrative Core is to provide the administrative support needed for the design and implementation of this program project. The Administrative Core will facilitate the interactions between the different program projects to ensure optimal communication, planning, data sharing and fiscal accounting.
The Specific Aims of the Core will be to provide fiscall oversight and overall management and coordination of the Program, ensure proper internal and external communications, establish and facilitate scientific review and planning, provide opportunities for training and career development, and develop, provide statistical consulting and oversee data and resource sharing. The Core will provide the staff support needed to administer the overall expenses for each of the separate projects and cores, and to insure fiscal responsibility. The Administrative Core will also assist in IRB application submissions and clinical trials reporting, report preparation, publication submissions, research and resource sharing, coordination of Internal Scientific Advisory Committee meetings, preparation of reports for the External Scientific Experts Group, and Internal Investigator meetings, and arranging scientific seminars and other communications between the investigators and the local research community.

Public Health Relevance

The Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is the cause of KS and two other AIDS-related malignancies. KS is the most common oral tumor associated with HIV/AIDS and is one of the most common pediatric and adult tumors in Sub-Saharan Africa. This project will investigate the immune control, activation, transmission and pathogenesis of KSHV in order to develop effective vaccines and therapeutics for this devastating viral pathogen.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE021954-02
Application #
8375649
Study Section
Special Emphasis Panel (ZDE1-MH)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
2
Fiscal Year
2012
Total Cost
$140,133
Indirect Cost
$76,250
Name
Seattle Children's Hospital
Department
Type
DUNS #
048682157
City
Seattle
State
WA
Country
United States
Zip Code
98105
Garrigues, H Jacques; Howard, Kellie; Barcy, Serge et al. (2017) Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication. J Virol 91:
Bruce, A Gregory; Barcy, Serge; DiMaio, Terri et al. (2017) Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial Cells. Pathogens 6:
DiMaio, Terri A; Wentz, Breanna L; Lagunoff, Michael (2016) Isolation and characterization of circulating lymphatic endothelial colony forming cells. Exp Cell Res 340:159-69
Lagunoff, Michael (2016) Activation of cellular metabolism during latent Kaposi's Sarcoma herpesvirus infection. Curr Opin Virol 19:45-9
Bruce, A Gregory; Horst, Jeremy A; Rose, Timothy M (2016) Conservation of the glycoprotein B homologs of the Kaposi?s sarcoma-associated herpesvirus (KSHV/HHV8) and old world primate rhadinoviruses of chimpanzees and macaques. Virology 494:29-46
Sanchez, Erica L; Lagunoff, Michael (2015) Viral activation of cellular metabolism. Virology 479-480:609-18
Fontaine, Krystal A; Sanchez, Erica L; Camarda, Roman et al. (2015) Dengue virus induces and requires glycolysis for optimal replication. J Virol 89:2358-66
Bruce, A Gregory; Thouless, Margaret E; Haines, Anthony S et al. (2015) Complete genome sequence of Pig-tailed macaque rhadinovirus 2 and its evolutionary relationship with rhesus macaque rhadinovirus and human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus. J Virol 89:3888-909
Blattman, Negin N; Lagunoff, Michael; Blattman, Joseph N et al. (2014) Nuclear factor kappa B is required for the production of infectious human herpesvirus 8 virions. Front Microbiol 5:129
Staheli, Jeannette P; Dyen, Michael R; Lewis, Patrick et al. (2014) Discovery and biological characterization of two novel pig-tailed macaque homologs of HHV-6 and HHV-7. Virology 471-473:126-40

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