The purpose of the Administrative Core is to provide the administrative support needed for the design and implementation of this program project. The Administrative Core will facilitate the interactions between the different program projects to ensure optimal communication, planning, data sharing and fiscal accounting.
The Specific Aims of the Core will be to provide fiscall oversight and overall management and coordination of the Program, ensure proper internal and external communications, establish and facilitate scientific review and planning, provide opportunities for training and career development, and develop, provide statistical consulting and oversee data and resource sharing. The Core will provide the staff support needed to administer the overall expenses for each of the separate projects and cores, and to insure fiscal responsibility. The Administrative Core will also assist in IRB application submissions and clinical trials reporting, report preparation, publication submissions, research and resource sharing, coordination of Internal Scientific Advisory Committee meetings, preparation of reports for the External Scientific Experts Group, and Internal Investigator meetings, and arranging scientific seminars and other communications between the investigators and the local research community.

Public Health Relevance

The Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is the cause of KS and two other AIDS-related malignancies. KS is the most common oral tumor associated with HIV/AIDS and is one of the most common pediatric and adult tumors in Sub-Saharan Africa. This project will investigate the immune control, activation, transmission and pathogenesis of KSHV in order to develop effective vaccines and therapeutics for this devastating viral pathogen.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Program Projects (P01)
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Special Emphasis Panel (ZDE1-MH)
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Seattle Children's Hospital
United States
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Garrigues, H Jacques; DeMaster, Laura K; Rubinchikova, Yelena E et al. (2014) KSHV attachment and entry are dependent on ?V?3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate. Virology 464-465:118-33
Fontaine, Krystal A; Camarda, Roman; Lagunoff, Michael (2014) Vaccinia virus requires glutamine but not glucose for efficient replication. J Virol 88:4366-74
Garrigues, H Jacques; Rubinchikova, Yelena E; Rose, Timothy M (2014) KSHV cell attachment sites revealed by ultra sensitive tyramide signal amplification (TSA) localize to membrane microdomains that are up-regulated on mitotic cells. Virology 452-453:75-85
Gutierrez, Kimberley D; Morris, Valerie A; Wu, David et al. (2013) Ets-1 is required for the activation of VEGFR3 during latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells. J Virol 87:6758-68
Morris, Valerie A; Punjabi, Almira S; Wells, Robert C et al. (2012) The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation. Virology 428:112-20
DiMaio, Terri A; Gutierrez, Kimberley D; Lagunoff, Michael (2011) Latent KSHV infection of endothelial cells induces integrin beta3 to activate angiogenic phenotypes. PLoS Pathog 7:e1002424