The purpose of the Administrative Core is to provide the administrative support needed for the design and implementation of this program project. The Administrative Core will facilitate the interactions between the different program projects to ensure optimal communication, planning, data sharing and fiscal accounting.
The Specific Aims of the Core will be to provide fiscall oversight and overall management and coordination of the Program, ensure proper internal and external communications, establish and facilitate scientific review and planning, provide opportunities for training and career development, and develop, provide statistical consulting and oversee data and resource sharing. The Core will provide the staff support needed to administer the overall expenses for each of the separate projects and cores, and to insure fiscal responsibility. The Administrative Core will also assist in IRB application submissions and clinical trials reporting, report preparation, publication submissions, research and resource sharing, coordination of Internal Scientific Advisory Committee meetings, preparation of reports for the External Scientific Experts Group, and Internal Investigator meetings, and arranging scientific seminars and other communications between the investigators and the local research community.

Public Health Relevance

The Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is the cause of KS and two other AIDS-related malignancies. KS is the most common oral tumor associated with HIV/AIDS and is one of the most common pediatric and adult tumors in Sub-Saharan Africa. This project will investigate the immune control, activation, transmission and pathogenesis of KSHV in order to develop effective vaccines and therapeutics for this devastating viral pathogen.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE021954-04
Application #
8657383
Study Section
Special Emphasis Panel (ZDE1)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98121
Ikoma, Minako; Gantt, Soren; Casper, Corey et al. (2018) KSHV oral shedding and plasma viremia result in significant changes in the extracellular tumorigenic miRNA expression profile in individuals infected with the malaria parasite. PLoS One 13:e0192659
Garrigues, H Jacques; Howard, Kellie; Barcy, Serge et al. (2017) Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication. J Virol 91:
Bruce, A Gregory; Barcy, Serge; DiMaio, Terri et al. (2017) Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial Cells. Pathogens 6:
Sychev, Zoi E; Hu, Alex; DiMaio, Terri A et al. (2017) Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism. PLoS Pathog 13:e1006256
Sanchez, Erica L; Pulliam, Thomas H; Dimaio, Terri A et al. (2017) Glycolysis, Glutaminolysis, and Fatty Acid Synthesis Are Required for Distinct Stages of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol 91:
DiMaio, Terri A; Wentz, Breanna L; Lagunoff, Michael (2016) Isolation and characterization of circulating lymphatic endothelial colony forming cells. Exp Cell Res 340:159-69
Bruce, A Gregory; Horst, Jeremy A; Rose, Timothy M (2016) Conservation of the glycoprotein B homologs of the Kaposi?s sarcoma-associated herpesvirus (KSHV/HHV8) and old world primate rhadinoviruses of chimpanzees and macaques. Virology 494:29-46
Lagunoff, Michael (2016) Activation of cellular metabolism during latent Kaposi's Sarcoma herpesvirus infection. Curr Opin Virol 19:45-9
Sanchez, Erica L; Carroll, Patrick A; Thalhofer, Angel B et al. (2015) Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival. PLoS Pathog 11:e1005052
Sanchez, Erica L; Lagunoff, Michael (2015) Viral activation of cellular metabolism. Virology 479-480:609-18

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