Drs. Potts and Kronenberg are responsible for overall direction of the projects and cores of this program project. They meet regularly, together and with principal investigators and core directors, to discuss ongoing research and to assure continuous integration of work by all participating groups. Further, as scientific opportunities arise, Drs. Potts and Kronenberg coordinate the modifications of aims and goals of each project and encourage new collaborative opportunities. To facilitate close interactions among participants in the program project and to share information with groups of other scientists whose research complements our own, regular research meetings are planned. The responsiveness and quality of the work of the core facilities are carefully monitored. Each week four meetings, open to all staff members and regularly attended by participants in this program project, are held within the Endocrine Unit. Drs. Potts and Kronenberg plan the topics to be discussed each week. The purpose of these informal and very interactive meetings is to present new ideas and seek input from colleagues about ongoing research. In addition, three journal clubs, each focused on a specific area pertinent to the Program Project (Gene Regulation &Development, Cell Signaling, and Clinical Research) meet weekly to discuss recent publications related to those topics. In addition, monthly meetings are held with four different groups of scientists from outside the Endocrine Unit (the MGH Renal Unit, scientists in the Center for Regenerative Medicine led by Dr. David Scadden, colleagues from the Harvard School of Dental Medicine and Harvard School of Public Health, and scientists in the Genetics Department at Harvard Medical School). These meetings provide critical forums for the sharing of information within the wider research community. All have attracted increasing interest from scientists within and outside MGH, expanding the range of topics presented and encouraging broader collaborations. The careful planning of Drs. Potts and Kronenberg is responsible for the success of these monthly meetings. Another vital function of the Core Directors is fiscal oversight for the program project. Centralization of administrative support functions necessary for monitoring program project resources is more cost-effective and efficient than distributing those responsibilities among the individual projects and cores. Reporting requirements, compliance with hospital and government regulations, and careful budgeting of expenses to prevent cost overruns help to assure that resources are appropriately allocated. These vital functions performed with direction from Drs. Potts and Kronenberg.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK011794-46
Application #
8659705
Study Section
Special Emphasis Panel (ZDK1-GRB-J (O1))
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
46
Fiscal Year
2014
Total Cost
$20,689
Indirect Cost
$8,799
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Wein, Marc N; Spatz, Jordan; Nishimori, Shigeki et al. (2015) HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. J Bone Miner Res 30:400-11
Manolagas, Stavros C; Kronenberg, Henry M (2014) Reproducibility of results in preclinical studies: a perspective from the bone field. J Bone Miner Res 29:2131-40
Javaheri, Behzad; Stern, Amber Rath; Lara, Nuria et al. (2014) Deletion of a single *-catenin allele in osteocytes abolishes the bone anabolic response to loading. J Bone Miner Res 29:705-15
Portale, Anthony A; Wolf, Myles; Juppner, Harald et al. (2014) Disordered FGF23 and mineral metabolism in children with CKD. Clin J Am Soc Nephrol 9:344-53
Gidon, Alexandre; Al-Bataineh, Mohammad M; Jean-Alphonse, Frederic G et al. (2014) Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nat Chem Biol 10:707-9
Dasgupta, Debayan; Wee, Mark J; Reyes, Monica et al. (2014) Mutations in SLC34A3/NPT2c are associated with kidney stones and nephrocalcinosis. J Am Soc Nephrol 25:2366-75
Vilardaga, Jean-Pierre; Jean-Alphonse, Frederic G; Gardella, Thomas J (2014) Endosomal generation of cAMP in GPCR signaling. Nat Chem Biol 10:700-6
Nistala, Harikiran; Mäkitie, Outi; Jüppner, Harald (2014) Caffey disease: new perspectives on old questions. Bone 60:246-51
Guo, Jun; Song, Lige; Liu, Minlin et al. (2013) Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice. Endocrinology 154:1680-9
Wesseling-Perry, Katherine; Pereira, Renata C; Tsai, Eileen et al. (2013) FGF23 and mineral metabolism in the early post-renal transplantation period. Pediatr Nephrol 28:2207-15

Showing the most recent 10 out of 166 publications