Drs. Potts and Kronenberg are responsible for overall direction of the projects and cores of this program project. They meet regularly, together and with principal investigators and core directors, to discuss ongoing research and to assure continuous integration of work by all participating groups. Further, as scientific opportunities arise, Drs. Potts and Kronenberg coordinate the modifications of aims and goals of each project and encourage new collaborative opportunities. To facilitate close interactions among participants in the program project and to share information with groups of other scientists whose research complements our own, regular research meetings are planned. The responsiveness and quality of the work of the core facilities are carefully monitored. Each week four meetings, open to all staff members and regularly attended by participants in this program project, are held within the Endocrine Unit. Drs. Potts and Kronenberg plan the topics to be discussed each week. The purpose of these informal and very interactive meetings is to present new ideas and seek input from colleagues about ongoing research. In addition, three journal clubs, each focused on a specific area pertinent to the Program Project (Gene Regulation & Development, Cell Signaling, and Clinical Research) meet weekly to discuss recent publications related to those topics. In addition, monthly meetings are held with four different groups of scientists from outside the Endocrine Unit (the MGH Renal Unit, scientists in the Center for Regenerative Medicine led by Dr. David Scadden, colleagues from the Harvard School of Dental Medicine and Harvard School of Public Health, and scientists in the Genetics Department at Harvard Medical School). These meetings provide critical forums for the sharing of information within the wider research community. All have attracted increasing interest from scientists within and outside MGH, expanding the range of topics presented and encouraging broader collaborations. The careful planning of Drs. Potts and Kronenberg is responsible for the success of these monthly meetings. Another vital function of the Core Directors is fiscal oversight for the program project. Centralization of administrative support functions necessary for monitoring program project resources is more cost-effective and efficient than distributing those responsibilities among the individual projects and cores. Reporting requirements, compliance with hospital and government regulations, and careful budgeting of expenses to prevent cost overruns help to assure that resources are appropriately allocated. These vital functions performed with direction from Drs. Potts and Kronenberg.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK011794-48
Application #
8959929
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
48
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
Christov, Marta; Clark, Abbe R; Corbin, Braden et al. (2018) Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. JCI Insight 3:
Dedic, Christopher; Hung, Tin Shing; Shipley, Alan M et al. (2018) Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes. Bone 116:135-143
Mizuhashi, Koji; Ono, Wanida; Matsushita, Yuki et al. (2018) Resting zone of the growth plate houses a unique class of skeletal stem cells. Nature 563:254-258
Hanna, Patrick; Grybek, Virginie; Perez de Nanclares, Guiomar et al. (2018) Genetic and Epigenetic Defects at the GNAS Locus Lead to Distinct Patterns of Skeletal Growth but Similar Early-Onset Obesity. J Bone Miner Res 33:1480-1488
Wein, Marc N; Foretz, Marc; Fisher, David E et al. (2018) Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab 29:723-735
Bastepe, Murat (2018) GNAS mutations and heterotopic ossification. Bone 109:80-85
Grigelioniene, Giedre; Nevalainen, Pasi I; Reyes, Monica et al. (2017) A Large Inversion Involving GNAS Exon A/B and All Exons Encoding Gs? Is Associated With Autosomal Dominant Pseudohypoparathyroidism Type Ib (PHP1B). J Bone Miner Res 32:776-783
Balani, Deepak H; Ono, Noriaki; Kronenberg, Henry M (2017) Parathyroid hormone regulates fates of murine osteoblast precursors in vivo. J Clin Invest 127:3327-3338
Cheloha, Ross W; Chen, Bingming; Kumar, Niyanta N et al. (2017) Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad ? Residue Distribution. J Med Chem 60:8816-8833
Mitchell, Deborah M; Jüppner, Harald; Burnett-Bowie, Sherri-Ann M (2017) FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls. J Clin Endocrinol Metab 102:1151-1160

Showing the most recent 10 out of 215 publications